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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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EIF4EBP1
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    TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

EIF4EBP1

Gene description

Eukaryotic translation initiation factor 4E binding protein 1

Protein class

Cancer-related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, including salivary gland, pancreas, the gastrointestinal tract and non-keratinized squamous epithelia.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA023501 , CAB005032 , CAB005039
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable) and endometrial cancer (unfavourable).
Renal cancer p<0.001
Endometrial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA023501
CAB005032
CAB005039

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer cells showed moderate to strong cytoplasmic and nuclear staining. Melanomas, prostate and colorectal cancers displayed moderate to strong cytoplasmic staining with additional nuclear immunoreactivity. A few cases of skin cancers displayed strong cytoplasmic staining. Several cases of female genital tract, pancreatic and lung cancers showed moderate cytoplasmic and nuclear staining. Gliomas and liver cancers were generally negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancers generally displayed moderate to strong immunoreactivity.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cytoplasmic and nuclear staining was seen in several cancers. Intensity was varying cancers between negative to strong.

GENE INFORMATION

Gene name

EIF4EBP1 (HGNC Symbol)

Synonyms

4E-BP1, PHAS-I

Description

Eukaryotic translation initiation factor 4E binding protein 1 (HGNC Symbol)

Entrez gene summary

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]

Chromosome

8

Cytoband

p11.23

Chromosome location (bp)

38030341 - 38060365

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000187840 (version 83.38)

Entrez gene

1978

UniProt

Q13541 (UniProt - Evidence at protein level)

neXtProt

NX_Q13541

Antibodypedia

EIF4EBP1 antibodies

PROTEIN BROWSER

EIF4EBP1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EIF4EBP1-001
ENSP00000340691
ENST00000338825
Q13541 [Direct mapping]
Eukaryotic translation initiation factor 4E-binding protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0002192 [IRES-dependent translational initiation]
GO:0002931 [response to ischemia]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0008190 [eukaryotic initiation factor 4E binding]
GO:0008286 [insulin receptor signaling pathway]
GO:0010467 [gene expression]
GO:0030324 [lung development]
GO:0030371 [translation repressor activity]
GO:0031333 [negative regulation of protein complex assembly]
GO:0031369 [translation initiation factor binding]
GO:0031929 [TOR signaling]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0045471 [response to ethanol]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0045947 [negative regulation of translational initiation]
GO:0051721 [protein phosphatase 2A binding]
GO:0071456 [cellular response to hypoxia]
Show all
118 aa
12.6 kDa
No 0

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