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EIF4EBP1

GENERAL INFORMATION

Gene name

 EIF4EBP1

Gene description

 Eukaryotic translation initiation factor 4E binding protein 1

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues, including salivary gland, pancreas, the gastrointestinal tract and non-keratinized squamous epithelia.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA023501 , CAB005032 , CAB005039
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Salivary gland

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 EIF4EBP1 (HGNC Symbol)

Synonyms

 4E-BP1, PHAS-I

Description

 Eukaryotic translation initiation factor 4E binding protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 p11.23

Chromosome location (bp)

 38030341 - 38060365

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000187840 (version 83.38)

Entrez gene

 1978

UniProt

 Q13541 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13541

Antibodypedia

 EIF4EBP1 antibodies

PROTEIN BROWSER
EIF4EBP1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EIF4EBP1-001
ENSP00000340691
ENST00000338825
Q13541 [Direct mapping]
Eukaryotic translation initiation factor 4E-binding protein 1
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Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0002192 [IRES-dependent translational initiation]
GO:0002931 [response to ischemia]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0008190 [eukaryotic initiation factor 4E binding]
GO:0008286 [insulin receptor signaling pathway]
GO:0010467 [gene expression]
GO:0030324 [lung development]
GO:0030371 [translation repressor activity]
GO:0031333 [negative regulation of protein complex assembly]
GO:0031369 [translation initiation factor binding]
GO:0031929 [TOR signaling]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0045471 [response to ethanol]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0045947 [negative regulation of translational initiation]
GO:0051721 [protein phosphatase 2A binding]
GO:0071456 [cellular response to hypoxia]
Show all
 118 aa
12.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.