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DNER

GENERAL INFORMATION

Gene name

 DNER

Gene description

 Delta/notch-like EGF repeat containing

Protein class

 Cancer-related genes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (glioma)
HPA (cell line):Group enriched (U-138 MG, U-87 MG)
HPA (normal tissue):Group enriched (adrenal gland, cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in cerebellar Purkinje cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA017320
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (unfavourable).
Liver cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA017320

GENE INFORMATION

Gene name

 DNER (HGNC Symbol)

Synonyms

 bet, UNQ26

Description

 Delta/notch-like EGF repeat containing (HGNC Symbol)

Entrez gene summary

Chromosome

 2

Cytoband

 q36.3

Chromosome location (bp)

 229357629 - 229714558

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000187957 (version 83.38)

Entrez gene

 92737

UniProt

 Q8NFT8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NFT8

Antibodypedia

 DNER antibodies

PROTEIN BROWSER
DNER-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DNER-001
ENSP00000345229
ENST00000341772
Q8NFT8 [Direct mapping]
Delta and Notch-like epidermal growth factor-related receptor
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001764 [neuron migration]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005112 [Notch binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0007219 [Notch signaling pathway]
GO:0007220 [Notch receptor processing]
GO:0007416 [synapse assembly]
GO:0007417 [central nervous system development]
GO:0010001 [glial cell differentiation]
GO:0016021 [integral component of membrane]
GO:0030276 [clathrin binding]
GO:0030425 [dendrite]
GO:0043025 [neuronal cell body]
GO:0048741 [skeletal muscle fiber development]
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 737 aa
78.5 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.