Expression of KLHL17 in cancer - Summary - The Human Protein Atlas

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KLHL17

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KLHL17
Gene description	Kelch-like family member 17
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in selected tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA031251
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), renal cancer (unfavourable) and cervical cancer (unfavourable).
Liver cancer p<0.001 Renal cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA031251

GENE INFORMATION
Gene name	KLHL17
Synonyms
Description	Kelch-like family member 17 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is expressed in neurons of most regions of the brain. It contains an N-terminal BTB domain, which mediates dimerization of the protein, and a C-terminal Kelch domain, which mediates binding to F-actin. This protein may play a key role in the regulation of actin-based neuronal function. [provided by RefSeq, Aug 2010]
Chromosome	1
Cytoband	p36.33
Chromosome location (bp)	960587 - 965715
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000187961 (version 83.38)
Entrez gene	339451
UniProt	Q6TDP4 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6TDP4
Antibodypedia	KLHL17 antibodies

PROTEIN BROWSER

KLHL17-001	KLHL17-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KLHL17-001 ENSP00000343930 ENST00000338591	Q6TDP4 [Direct mapping] Kelch-like protein 17 Show all	Predicted intracellular proteins Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0007420 [brain development] GO:0014069 [postsynaptic density] GO:0015629 [actin cytoskeleton] GO:0016567 [protein ubiquitination] GO:0030036 [actin cytoskeleton organization] GO:0030054 [cell junction] GO:0031208 [POZ domain binding] GO:0031463 [Cul3-RING ubiquitin ligase complex] GO:0032839 [dendrite cytoplasm] GO:0032947 [protein complex scaffold] GO:0043025 [neuronal cell body] GO:0045211 [postsynaptic membrane] GO:0051015 [actin filament binding] Show all	642 aa 69.9 kDa	No	0
KLHL17-201 ENSP00000479477 ENST00000622660	Q0VGE6 [Direct mapping] KLHL17 protein; Kelch-like 17 (Drosophila), isoform CRA_c; Kelch-like protein 17 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0016567 [protein ubiquitination] GO:0051015 [actin filament binding] Show all	225 aa 24.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.