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KLHL17

GENERAL INFORMATION

Gene name

 KLHL17

Gene description

 Kelch-like family member 17

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in selected tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA031251
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 KLHL17

Synonyms

Description

 Kelch-like family member 17 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is expressed in neurons of most regions of the brain. It contains an N-terminal BTB domain, which mediates dimerization of the protein, and a C-terminal Kelch domain, which mediates binding to F-actin. This protein may play a key role in the regulation of actin-based neuronal function. [provided by RefSeq, Aug 2010]

Chromosome

 1

Cytoband

 p36.33

Chromosome location (bp)

 960587 - 965715

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000187961 (version 83.38)

Entrez gene

 339451

UniProt

 Q6TDP4 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q6TDP4

Antibodypedia

 KLHL17 antibodies

PROTEIN BROWSER
KLHL17-001
KLHL17-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KLHL17-001
ENSP00000343930
ENST00000338591
Q6TDP4 [Direct mapping]
Kelch-like protein 17
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Predicted intracellular proteins
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GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0007420 [brain development]
GO:0014069 [postsynaptic density]
GO:0015629 [actin cytoskeleton]
GO:0016567 [protein ubiquitination]
GO:0030036 [actin cytoskeleton organization]
GO:0030054 [cell junction]
GO:0031208 [POZ domain binding]
GO:0031463 [Cul3-RING ubiquitin ligase complex]
GO:0032839 [dendrite cytoplasm]
GO:0032947 [protein complex scaffold]
GO:0043025 [neuronal cell body]
GO:0045211 [postsynaptic membrane]
GO:0051015 [actin filament binding]
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 642 aa
69.9 kDa 		No 0
KLHL17-201
ENSP00000479477
ENST00000622660
Q0VGE6 [Direct mapping]
KLHL17 protein; Kelch-like 17 (Drosophila), isoform CRA_c; Kelch-like protein 17
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Predicted intracellular proteins
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GO:0005515 [protein binding]
GO:0016567 [protein ubiquitination]
GO:0051015 [actin filament binding]
Show all
 225 aa
24.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.