Fields »
ABOUT
HELP
BLOG
MAPK12

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 MAPK12

Gene description

 Mitogen-activated protein kinase 12

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nuclear speckles. In addition localized to the cytosol.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nuclear speckles (approved)

Additional location

 In addition localized to the Cytosol (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
CAB025483
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nuclear speckles. In addition localized to the cytosol.

Main location

 Nuclear speckles (approved)

Additional location

 Cytosol (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB025483 U-251 MG Nuclear speckles Intensity
Cytosol

GENE INFORMATION

Gene name

 MAPK12 (HGNC Symbol)

Synonyms

 ERK6, p38gamma, PRKM12, SAPK-3, SAPK3

Description

 Mitogen-activated protein kinase 12 (HGNC Symbol)

Entrez gene summary

 Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. [provided by RefSeq, Jul 2008]

Chromosome

 22

Cytoband

 q13.33

Chromosome location (bp)

 50245450 - 50261825

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000188130 (version 83.38)

Entrez gene

 6300

UniProt

 P53778 (UniProt - Evidence at protein level)

neXtProt

 NX_P53778

Antibodypedia

 MAPK12 antibodies

PROTEIN BROWSER
MAPK12-001
MAPK12-004
MAPK12-009
MAPK12-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAPK12-001
ENSP00000215659
ENST00000215659
P53778 [Direct mapping]
Mitogen-activated protein kinase 12
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000287 [magnesium ion binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006975 [DNA damage induced protein phosphorylation]
GO:0006996 [organelle organization]
GO:0007005 [mitochondrion organization]
GO:0007050 [cell cycle arrest]
GO:0007165 [signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007517 [muscle organ development]
GO:0010952 [positive regulation of peptidase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0042692 [muscle cell differentiation]
GO:0045445 [myoblast differentiation]
GO:0045786 [negative regulation of cell cycle]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051149 [positive regulation of muscle cell differentiation]
Show all
 367 aa
41.9 kDa 		No 0
MAPK12-004
ENSP00000379126
ENST00000395780
B5MDL5 [Direct mapping]
Mitogen-activated protein kinase 12; Mitogen-activated protein kinase 12, isoform CRA_a
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0004672 [protein kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
Show all
 277 aa
31.8 kDa 		No 0
MAPK12-009
ENSP00000379124
ENST00000395778
A8MY48 [Direct mapping]
Mitogen-activated protein kinase 12
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 119 aa
13.4 kDa 		No 0
MAPK12-201
ENSP00000479972
ENST00000622558
P53778 [Direct mapping]
Mitogen-activated protein kinase 12
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000287 [magnesium ion binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006975 [DNA damage induced protein phosphorylation]
GO:0006996 [organelle organization]
GO:0007005 [mitochondrion organization]
GO:0007050 [cell cycle arrest]
GO:0007165 [signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007517 [muscle organ development]
GO:0010952 [positive regulation of peptidase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0042692 [muscle cell differentiation]
GO:0045445 [myoblast differentiation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051149 [positive regulation of muscle cell differentiation]
Show all
 357 aa
40.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.