Cell atlas - CENPP - The Human Protein Atlas

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CENPP

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli
	Nucleus

Human cell
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CENPP
Gene description	Centromere protein P
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus. In addition localized to the nucleoli.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported)
Additional location	In addition localized to the Nucleoli (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA058945
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus. In addition localized to the nucleoli.

Main location

Nucleus (supported)

Additional location

Nucleoli (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA058945	RH-30	Nucleus
	HPA058945	RH-30	Nucleoli
	HPA058945	RT4	Nucleus
	HPA058945	RT4	Nucleoli
	HPA058945	U-2 OS	Nucleus
	HPA058945	U-2 OS	Nucleoli

GENE INFORMATION
Gene name	CENPP (HGNC Symbol)
Synonyms	CENP-P, RP11-19J3.3
Description	Centromere protein P (HGNC Symbol)
Entrez gene summary	CENPP is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]
Chromosome	9
Cytoband	q22.31
Chromosome location (bp)	92325484 - 92620533
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000188312 (version 83.38)
Entrez gene	401541
UniProt	Q6IPU0 (UniProt - Evidence at protein level)
neXtProt	NX_Q6IPU0
Antibodypedia	CENPP antibodies

PROTEIN BROWSER

CENPP-001	CENPP-002	CENPP-003	CENPP-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CENPP-001 ENSP00000364729 ENST00000375579	Q6IPU0 [Direct mapping] Centromere protein P Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000775 [chromosome, centromeric region] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0006334 [nucleosome assembly] GO:0007264 [small GTPase mediated signal transduction] GO:0034080 [CENP-A containing nucleosome assembly] Show all	115 aa 12.7 kDa	No	0
CENPP-002 ENSP00000364726 ENST00000375576	X6R9C8 [Direct mapping] Centromere protein P; HCG1643604 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000775 [chromosome, centromeric region] GO:0034080 [CENP-A containing nucleosome assembly] Show all	102 aa 11.3 kDa	No	0
CENPP-003 ENSP00000364737 ENST00000375587	Q6IPU0 [Direct mapping] Centromere protein P Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000775 [chromosome, centromeric region] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0006334 [nucleosome assembly] GO:0007264 [small GTPase mediated signal transduction] GO:0034080 [CENP-A containing nucleosome assembly] Show all	288 aa 33.2 kDa	No	0
CENPP-201 ENSP00000477821 ENST00000618653	A0A087WTF1 [Direct mapping] Centromere protein P Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000775 [chromosome, centromeric region] GO:0034080 [CENP-A containing nucleosome assembly] Show all	190 aa 22.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.