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CENPP

GENERAL INFORMATION

Gene name

 CENPP

Gene description

 Centromere protein P

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enhanced (skin)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Widely distributed nuclear expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Cytoplasmic staining observed and disregarded.

Reliability score

 Uncertain based on 1 antibody.
HPA021787
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable) and cervical cancer (favourable).
Head and neck cancer p<0.001
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA021787

GENE INFORMATION

Gene name

 CENPP (HGNC Symbol)

Synonyms

 CENP-P, RP11-19J3.3

Description

 Centromere protein P (HGNC Symbol)

Entrez gene summary

 CENPP is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]

Chromosome

 9

Cytoband

 q22.31

Chromosome location (bp)

 92325484 - 92620533

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000188312 (version 83.38)

Entrez gene

 401541

UniProt

 Q6IPU0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6IPU0

Antibodypedia

 CENPP antibodies

PROTEIN BROWSER
CENPP-001
CENPP-002
CENPP-003
CENPP-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CENPP-001
ENSP00000364729
ENST00000375579
Q6IPU0 [Direct mapping]
Centromere protein P
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006334 [nucleosome assembly]
GO:0007264 [small GTPase mediated signal transduction]
GO:0034080 [CENP-A containing nucleosome assembly]
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 115 aa
12.7 kDa 		No 0
CENPP-002
ENSP00000364726
ENST00000375576
X6R9C8 [Direct mapping]
Centromere protein P; HCG1643604
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000775 [chromosome, centromeric region]
GO:0034080 [CENP-A containing nucleosome assembly]
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 102 aa
11.3 kDa 		No 0
CENPP-003
ENSP00000364737
ENST00000375587
Q6IPU0 [Direct mapping]
Centromere protein P
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006334 [nucleosome assembly]
GO:0007264 [small GTPase mediated signal transduction]
GO:0034080 [CENP-A containing nucleosome assembly]
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 288 aa
33.2 kDa 		No 0
CENPP-201
ENSP00000477821
ENST00000618653
A0A087WTF1 [Direct mapping]
Centromere protein P
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000775 [chromosome, centromeric region]
GO:0034080 [CENP-A containing nucleosome assembly]
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 190 aa
22.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.