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PLSCR1

GENERAL INFORMATION

Gene name

 PLSCR1

Gene description

 Phospholipid scramblase 1

Protein class

 Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V, SK-MEL-30)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in subsets of immune cells in several tissues, incuding lymphoid organs.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB070421
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB070421

GENE INFORMATION

Gene name

 PLSCR1 (HGNC Symbol)

Synonyms

 MMTRA1B

Description

 Phospholipid scramblase 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 3

Cytoband

 q24

Chromosome location (bp)

 146515180 - 146544864

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000188313 (version 83.38)

Entrez gene

 5359

UniProt

 O15162 (UniProt - Evidence at protein level)

neXtProt

 NX_O15162

Antibodypedia

 PLSCR1 antibodies

PROTEIN BROWSER
PLSCR1-001
PLSCR1-002
PLSCR1-003
PLSCR1-007
PLSCR1-011
PLSCR1-014
PLSCR1-018

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PLSCR1-001
ENSP00000345494
ENST00000342435
O15162 [Direct mapping]
Phospholipid scramblase 1
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Transporters
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005154 [epidermal growth factor receptor binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006659 [phosphatidylserine biosynthetic process]
GO:0006915 [apoptotic process]
GO:0006953 [acute-phase response]
GO:0010628 [positive regulation of gene expression]
GO:0016020 [membrane]
GO:0017121 [phospholipid scrambling]
GO:0017124 [SH3 domain binding]
GO:0017128 [phospholipid scramblase activity]
GO:0019899 [enzyme binding]
GO:0030168 [platelet activation]
GO:0031012 [extracellular matrix]
GO:0033003 [regulation of mast cell activation]
GO:0035456 [response to interferon-beta]
GO:0042609 [CD4 receptor binding]
GO:0045071 [negative regulation of viral genome replication]
GO:0045089 [positive regulation of innate immune response]
GO:0045121 [membrane raft]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051607 [defense response to virus]
GO:0060368 [regulation of Fc receptor mediated stimulatory signaling pathway]
GO:0070062 [extracellular exosome]
GO:2000373 [positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity]
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 318 aa
35 kDa 		No 0
PLSCR1-002
ENSP00000417792
ENST00000487389
C9J7K9 [Direct mapping]
Phospholipid scramblase 1; Phospholipid scramblase 1, isoform CRA_g
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 311 aa
34.2 kDa 		No 0
PLSCR1-003
ENSP00000411675
ENST00000448787
O15162 [Direct mapping]
Phospholipid scramblase 1
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Transporters
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005154 [epidermal growth factor receptor binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006659 [phosphatidylserine biosynthetic process]
GO:0006915 [apoptotic process]
GO:0006953 [acute-phase response]
GO:0010628 [positive regulation of gene expression]
GO:0016020 [membrane]
GO:0017121 [phospholipid scrambling]
GO:0017124 [SH3 domain binding]
GO:0017128 [phospholipid scramblase activity]
GO:0019899 [enzyme binding]
GO:0030168 [platelet activation]
GO:0031012 [extracellular matrix]
GO:0033003 [regulation of mast cell activation]
GO:0035456 [response to interferon-beta]
GO:0042609 [CD4 receptor binding]
GO:0045071 [negative regulation of viral genome replication]
GO:0045089 [positive regulation of innate immune response]
GO:0045121 [membrane raft]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051607 [defense response to virus]
GO:0060368 [regulation of Fc receptor mediated stimulatory signaling pathway]
GO:0070062 [extracellular exosome]
GO:2000373 [positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity]
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 237 aa
26.8 kDa 		No 0
PLSCR1-007
ENSP00000420523
ENST00000472349
C9JE06 [Direct mapping]
Phospholipid scramblase 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 249 aa
27.3 kDa 		No 0
PLSCR1-011
ENSP00000418550
ENST00000486631
C9J0H3 [Direct mapping]
Phospholipid scramblase 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 171 aa
19.4 kDa 		No 0
PLSCR1-014
ENSP00000418103
ENST00000462666
C9J9P4 [Direct mapping]
Phospholipid scramblase 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 248 aa
27.1 kDa 		No 0
PLSCR1-018
ENSP00000420006
ENST00000483300
H7C5I5 [Direct mapping]
Phospholipid scramblase 1
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 171 aa
18.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.