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NBR1

GENERAL INFORMATION

Gene name

 NBR1

Gene description

 Neighbor of BRCA1 gene 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA022999 , HPA023999
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA022999
HPA023999

GENE INFORMATION

Gene name

 NBR1 (HGNC Symbol)

Synonyms

 1A1-3B, CA125, KIAA0049, M17S2

Description

 Neighbor of BRCA1 gene 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Chromosome

 17

Cytoband

 q21.31

Chromosome location (bp)

 43170481 - 43211689

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000188554 (version 83.38)

Entrez gene

 4077

UniProt

 Q14596 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14596

Antibodypedia

 NBR1 antibodies

PROTEIN BROWSER
NBR1-001
NBR1-002
NBR1-003
NBR1-004
NBR1-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NBR1-001
ENSP00000343479
ENST00000341165
Q14596 [Direct mapping]
Next to BRCA1 gene 1 protein
A0A024R1V3 [Target identity:100%; Query identity:100%]
Neighbor of BRCA1 gene 1, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000407 [pre-autophagosomal structure]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005764 [lysosome]
GO:0005770 [late endosome]
GO:0005776 [autophagosome]
GO:0005829 [cytosol]
GO:0008270 [zinc ion binding]
GO:0016020 [membrane]
GO:0016236 [macroautophagy]
GO:0030500 [regulation of bone mineralization]
GO:0031410 [cytoplasmic vesicle]
GO:0031430 [M band]
GO:0032872 [regulation of stress-activated MAPK cascade]
GO:0043130 [ubiquitin binding]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0051019 [mitogen-activated protein kinase binding]
GO:0051259 [protein oligomerization]
GO:0070062 [extracellular exosome]
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 966 aa
107.4 kDa 		No 0
NBR1-002
ENSP00000437545
ENST00000542611
B7Z5R6 [Direct mapping]
Next to BRCA1 gene 1 protein; cDNA FLJ55359, highly similar to Next to BRCA1 gene 1 protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000407 [pre-autophagosomal structure]
GO:0005776 [autophagosome]
GO:0008270 [zinc ion binding]
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 837 aa
92.9 kDa 		No 0
NBR1-003
ENSP00000466667
ENST00000590996
Q14596 [Direct mapping]
Next to BRCA1 gene 1 protein
A0A024R1V3 [Target identity:100%; Query identity:100%]
Neighbor of BRCA1 gene 1, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000407 [pre-autophagosomal structure]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005764 [lysosome]
GO:0005770 [late endosome]
GO:0005776 [autophagosome]
GO:0005829 [cytosol]
GO:0008270 [zinc ion binding]
GO:0016020 [membrane]
GO:0016236 [macroautophagy]
GO:0030500 [regulation of bone mineralization]
GO:0031410 [cytoplasmic vesicle]
GO:0031430 [M band]
GO:0032872 [regulation of stress-activated MAPK cascade]
GO:0043130 [ubiquitin binding]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0051019 [mitogen-activated protein kinase binding]
GO:0051259 [protein oligomerization]
GO:0070062 [extracellular exosome]
Show all
 966 aa
107.4 kDa 		No 0
NBR1-004
ENSP00000467816
ENST00000589872
Q14596 [Direct mapping]
Next to BRCA1 gene 1 protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000407 [pre-autophagosomal structure]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005764 [lysosome]
GO:0005770 [late endosome]
GO:0005776 [autophagosome]
GO:0005829 [cytosol]
GO:0008270 [zinc ion binding]
GO:0016020 [membrane]
GO:0016236 [macroautophagy]
GO:0030500 [regulation of bone mineralization]
GO:0031410 [cytoplasmic vesicle]
GO:0031430 [M band]
GO:0032872 [regulation of stress-activated MAPK cascade]
GO:0043130 [ubiquitin binding]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0051019 [mitogen-activated protein kinase binding]
GO:0051259 [protein oligomerization]
GO:0070062 [extracellular exosome]
Show all
 937 aa
103.8 kDa 		No 0
NBR1-007
ENSP00000466071
ENST00000586650
A0A0C4DGP6 [Direct mapping]
Next to BRCA1 gene 1 protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000407 [pre-autophagosomal structure]
GO:0005776 [autophagosome]
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 42 aa
4.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.