Cell atlas - ASAH2 - The Human Protein Atlas

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ASAH2

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Focal adhesion sites

Human cell
	Actin Filaments

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GENERAL INFORMATION
Gene name	ASAH2
Gene description	N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the focal adhesion sites. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Focal adhesion sites (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA061171
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the focal adhesion sites. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Focal adhesion sites (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA061171	U-2 OS	Focal adhesion sites
	HPA061171	U-251 MG	Focal adhesion sites

GENE INFORMATION
Gene name	ASAH2
Synonyms
Description	N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 (HGNC Symbol)
Entrez gene summary	Ceramidases (EC 3.5.1.23), such as ASAH2, catalyze hydrolysis of the N-acyl linkage of ceramide, a second messenger in a variety of cellular events, to produce sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger (see MIM 603730) (Mitsutake et al., 2001 [PubMed 11328816]).[supplied by OMIM, Mar 2008]
Chromosome	10
Cytoband	q11.23
Chromosome location (bp)	50182778 - 50248610
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000188611 (version 83.38)
Entrez gene	56624
UniProt	Q9NR71 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NR71
Antibodypedia	ASAH2 antibodies

PROTEIN BROWSER

ASAH2-001	ASAH2-003	ASAH2-004	ASAH2-201	ASAH2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ASAH2-001 ENSP00000378897 ENST00000395526	Q9NR71 [Direct mapping] Neutral ceramidase Neutral ceramidase soluble form Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005576 [extracellular region] GO:0005739 [mitochondrion] GO:0005886 [plasma membrane] GO:0006672 [ceramide metabolic process] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0016021 [integral component of membrane] GO:0017040 [ceramidase activity] GO:0042759 [long-chain fatty acid biosynthetic process] GO:0046512 [sphingosine biosynthetic process] GO:0046514 [ceramide catabolic process] Show all	780 aa 85.5 kDa	No	0
ASAH2-003 ENSP00000329886 ENST00000329428	A0A0C4DFQ8 [Direct mapping] Neutral ceramidase Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		726 aa 79.5 kDa	Yes	0
ASAH2-004 ENSP00000476827 ENST00000489640	V9GYJ5 [Direct mapping] Neutral ceramidase Show all	Predicted intracellular proteins Show all		144 aa 16.2 kDa	No	0
ASAH2-201 ENSP00000392766 ENST00000443575	E9PBM9 [Direct mapping] Neutral ceramidase Show all	Predicted intracellular proteins Show all		622 aa 68.7 kDa	No	0
ASAH2-202 ENSP00000388206 ENST00000447815	Q9NR71 [Direct mapping] Neutral ceramidase Neutral ceramidase soluble form Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005576 [extracellular region] GO:0005739 [mitochondrion] GO:0005886 [plasma membrane] GO:0006672 [ceramide metabolic process] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0016021 [integral component of membrane] GO:0017040 [ceramidase activity] GO:0042759 [long-chain fatty acid biosynthetic process] GO:0046512 [sphingosine biosynthetic process] GO:0046514 [ceramide catabolic process] Show all	745 aa 81.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.