Expression of ASAH2 in cancer - Summary - The Human Protein Atlas

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ASAH2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ASAH2
Gene description	N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Mixed
HPA (normal tissue):	Group enriched (duodenum, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct luminal membranous expression in small intestine and duodenum.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 1 antibody. HPA061171
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA061171

GENE INFORMATION
Gene name	ASAH2
Synonyms
Description	N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 (HGNC Symbol)
Entrez gene summary	Ceramidases (EC 3.5.1.23), such as ASAH2, catalyze hydrolysis of the N-acyl linkage of ceramide, a second messenger in a variety of cellular events, to produce sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger (see MIM 603730) (Mitsutake et al., 2001 [PubMed 11328816]).[supplied by OMIM, Mar 2008]
Chromosome	10
Cytoband	q11.23
Chromosome location (bp)	50182778 - 50248610
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000188611 (version 83.38)
Entrez gene	56624
UniProt	Q9NR71 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NR71
Antibodypedia	ASAH2 antibodies

PROTEIN BROWSER

ASAH2-001	ASAH2-003	ASAH2-004	ASAH2-201	ASAH2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ASAH2-001 ENSP00000378897 ENST00000395526	Q9NR71 [Direct mapping] Neutral ceramidase Neutral ceramidase soluble form Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005576 [extracellular region] GO:0005739 [mitochondrion] GO:0005886 [plasma membrane] GO:0006672 [ceramide metabolic process] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0016021 [integral component of membrane] GO:0017040 [ceramidase activity] GO:0042759 [long-chain fatty acid biosynthetic process] GO:0046512 [sphingosine biosynthetic process] GO:0046514 [ceramide catabolic process] Show all	780 aa 85.5 kDa	No	0
ASAH2-003 ENSP00000329886 ENST00000329428	A0A0C4DFQ8 [Direct mapping] Neutral ceramidase Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		726 aa 79.5 kDa	Yes	0
ASAH2-004 ENSP00000476827 ENST00000489640	V9GYJ5 [Direct mapping] Neutral ceramidase Show all	Predicted intracellular proteins Show all		144 aa 16.2 kDa	No	0
ASAH2-201 ENSP00000392766 ENST00000443575	E9PBM9 [Direct mapping] Neutral ceramidase Show all	Predicted intracellular proteins Show all		622 aa 68.7 kDa	No	0
ASAH2-202 ENSP00000388206 ENST00000447815	Q9NR71 [Direct mapping] Neutral ceramidase Neutral ceramidase soluble form Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005576 [extracellular region] GO:0005739 [mitochondrion] GO:0005886 [plasma membrane] GO:0006672 [ceramide metabolic process] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0016021 [integral component of membrane] GO:0017040 [ceramidase activity] GO:0042759 [long-chain fatty acid biosynthetic process] GO:0046512 [sphingosine biosynthetic process] GO:0046514 [ceramide catabolic process] Show all	745 aa 81.7 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.