Expression of ZDHHC9 in cancer - Summary - The Human Protein Atlas

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ZDHHC9

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ZDHHC9
Gene description	Zinc finger, DHHC-type containing 9
Protein class	Disease related genes Enzymes Potential drug targets Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA031814
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (unfavourable), breast cancer (unfavourable) and head and neck cancer (unfavourable).
Cervical cancer p<0.001 Breast cancer p<0.001 Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA031814

GENE INFORMATION
Gene name	ZDHHC9 (HGNC Symbol)
Synonyms	CGI-89, CXorf11, ZDHHC10, ZNF379, ZNF380
Description	Zinc finger, DHHC-type containing 9 (HGNC Symbol)
Entrez gene summary	This gene encodes an integral membrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein forms a complex with golgin subfamily A member 7 and functions as a palmitoyltransferase. This protein specifically palmitoylates HRAS and NRAS. Mutations in this gene are associated with X-linked mental retardation. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, May 2010]
Chromosome	X
Cytoband	q26.1
Chromosome location (bp)	129803288 - 129843909
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000188706 (version 83.38)
Entrez gene	51114
UniProt	Q9Y397 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y397
Antibodypedia	ZDHHC9 antibodies

PROTEIN BROWSER

ZDHHC9-001	ZDHHC9-002	ZDHHC9-004	ZDHHC9-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZDHHC9-001 ENSP00000349689 ENST00000357166	Q9Y397 [Direct mapping] Palmitoyltransferase ZDHHC9 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0002178 [palmitoyltransferase complex] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0006612 [protein targeting to membrane] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0016409 [palmitoyltransferase activity] GO:0018230 [peptidyl-L-cysteine S-palmitoylation] GO:0018345 [protein palmitoylation] GO:0019706 [protein-cysteine S-palmitoyltransferase activity] GO:0031228 [intrinsic component of Golgi membrane] GO:0043849 [Ras palmitoyltransferase activity] Show all	364 aa 40.9 kDa	No	4
ZDHHC9-002 ENSP00000406165 ENST00000433917	H0Y6K6 [Direct mapping] Palmitoyltransferase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0008152 [metabolic process] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0019706 [protein-cysteine S-palmitoyltransferase activity] Show all	194 aa 21.5 kDa	No	2
ZDHHC9-004 ENSP00000383991 ENST00000406492	Q5JYE8 [Direct mapping] Palmitoyltransferase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0008152 [metabolic process] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0019706 [protein-cysteine S-palmitoyltransferase activity] Show all	170 aa 19.4 kDa	No	3
ZDHHC9-005 ENSP00000360103 ENST00000371064	Q9Y397 [Direct mapping] Palmitoyltransferase ZDHHC9 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0002178 [palmitoyltransferase complex] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0006612 [protein targeting to membrane] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0016409 [palmitoyltransferase activity] GO:0018230 [peptidyl-L-cysteine S-palmitoylation] GO:0018345 [protein palmitoylation] GO:0019706 [protein-cysteine S-palmitoyltransferase activity] GO:0031228 [intrinsic component of Golgi membrane] GO:0043849 [Ras palmitoyltransferase activity] Show all	364 aa 40.9 kDa	No	4

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The Human Protein Atlas

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