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SLX4

GENERAL INFORMATION

Gene name

 SLX4

Gene description

 SLX4 structure-specific endonuclease subunit

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear staining in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA066238
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA066238

GENE INFORMATION

Gene name

 SLX4 (HGNC Symbol)

Synonyms

 BTBD12, FANCP, KIAA1784, KIAA1987

Description

 SLX4 structure-specific endonuclease subunit (HGNC Symbol)

Entrez gene summary

 This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.[provided by RefSeq, Jan 2011]

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 3581181 - 3611598

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000188827 (version 83.38)

Entrez gene

 84464

UniProt

 Q8IY92 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IY92

Antibodypedia

 SLX4 antibodies

PROTEIN BROWSER
SLX4-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLX4-001
ENSP00000294008
ENST00000294008
Q8IY92 [Direct mapping]
Structure-specific endonuclease subunit SLX4
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000724 [double-strand break repair via homologous recombination]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0000790 [nuclear chromatin]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006289 [nucleotide-excision repair]
GO:0006302 [double-strand break repair]
GO:0008047 [enzyme activator activity]
GO:0008821 [crossover junction endodeoxyribonuclease activity]
GO:0010792 [DNA double-strand break processing involved in repair via single-strand annealing]
GO:0017108 [5'-flap endonuclease activity]
GO:0030054 [cell junction]
GO:0033557 [Slx1-Slx4 complex]
GO:0036297 [interstrand cross-link repair]
GO:0043085 [positive regulation of catalytic activity]
GO:0048257 [3'-flap endonuclease activity]
GO:0048476 [Holliday junction resolvase complex]
GO:0070522 [ERCC4-ERCC1 complex]
GO:0072429 [response to intra-S DNA damage checkpoint signaling]
GO:0090656 [t-circle formation]
GO:1904431 [positive regulation of t-circle formation]
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 1834 aa
200 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.