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This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]
SCAMPI predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases Kinases TKL Ser/Thr protein kinases SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000149 [SNARE binding] GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0000187 [activation of MAPK activity] GO:0001933 [negative regulation of protein phosphorylation] GO:0001934 [positive regulation of protein phosphorylation] GO:0001948 [glycoprotein binding] GO:0003779 [actin binding] GO:0003924 [GTPase activity] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004708 [MAP kinase kinase activity] GO:0005096 [GTPase activator activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005525 [GTP binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005743 [mitochondrial inner membrane] GO:0005759 [mitochondrial matrix] GO:0005764 [lysosome] GO:0005768 [endosome] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005798 [Golgi-associated vesicle] GO:0005802 [trans-Golgi network] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006897 [endocytosis] GO:0006914 [autophagy] GO:0006979 [response to oxidative stress] GO:0007005 [mitochondrion organization] GO:0007030 [Golgi organization] GO:0007040 [lysosome organization] GO:0007264 [small GTPase mediated signal transduction] GO:0007528 [neuromuscular junction development] GO:0008021 [synaptic vesicle] GO:0008340 [determination of adult lifespan] GO:0010508 [positive regulation of autophagy] GO:0010738 [regulation of protein kinase A signaling] GO:0010955 [negative regulation of protein processing] GO:0014041 [regulation of neuron maturation] GO:0015031 [protein transport] GO:0015631 [tubulin binding] GO:0016020 [membrane] GO:0016234 [inclusion body] GO:0016301 [kinase activity] GO:0017048 [Rho GTPase binding] GO:0017075 [syntaxin-1 binding] GO:0018105 [peptidyl-serine phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0019722 [calcium-mediated signaling] GO:0021772 [olfactory bulb development] GO:0022028 [tangential migration from the subventricular zone to the olfactory bulb] GO:0030054 [cell junction] GO:0030159 [receptor signaling complex scaffold activity] GO:0030276 [clathrin binding] GO:0030424 [axon] GO:0030425 [dendrite] GO:0030426 [growth cone] GO:0030529 [ribonucleoprotein complex] GO:0030672 [synaptic vesicle membrane] GO:0031398 [positive regulation of protein ubiquitination] GO:0031410 [cytoplasmic vesicle] GO:0031966 [mitochondrial membrane] GO:0032091 [negative regulation of protein binding] GO:0032092 [positive regulation of protein binding] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032473 [cytoplasmic side of mitochondrial outer membrane] GO:0032839 [dendrite cytoplasm] GO:0034211 [GTP-dependent protein kinase activity] GO:0034260 [negative regulation of GTPase activity] GO:0034599 [cellular response to oxidative stress] GO:0034613 [cellular protein localization] GO:0035556 [intracellular signal transduction] GO:0035564 [regulation of kidney size] GO:0035640 [exploration behavior] GO:0035641 [locomotory exploration behavior] GO:0036479 [peroxidase inhibitor activity] GO:0040012 [regulation of locomotion] GO:0042391 [regulation of membrane potential] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043005 [neuron projection] GO:0043025 [neuronal cell body] GO:0043068 [positive regulation of programmed cell death] GO:0043195 [terminal bouton] GO:0043204 [perikaryon] GO:0043231 [intracellular membrane-bounded organelle] GO:0043406 [positive regulation of MAP kinase activity] GO:0043547 [positive regulation of GTPase activity] GO:0044325 [ion channel binding] GO:0045121 [membrane raft] GO:0045202 [synapse] GO:0046039 [GTP metabolic process] GO:0046777 [protein autophosphorylation] GO:0048312 [intracellular distribution of mitochondria] GO:0048812 [neuron projection morphogenesis] GO:0051018 [protein kinase A binding] GO:0051646 [mitochondrion localization] GO:0051900 [regulation of mitochondrial depolarization] GO:0051966 [regulation of synaptic transmission, glutamatergic] GO:0060079 [excitatory postsynaptic potential] GO:0060159 [regulation of dopamine receptor signaling pathway] GO:0060161 [positive regulation of dopamine receptor signaling pathway] GO:0060828 [regulation of canonical Wnt signaling pathway] GO:0061001 [regulation of dendritic spine morphogenesis] GO:0070062 [extracellular exosome] GO:0070585 [protein localization to mitochondrion] GO:0070997 [neuron death] GO:0071287 [cellular response to manganese ion] GO:0071407 [cellular response to organic cyclic compound] GO:0072593 [reactive oxygen species metabolic process] GO:0090140 [regulation of mitochondrial fission] GO:0090263 [positive regulation of canonical Wnt signaling pathway] GO:0090394 [negative regulation of excitatory postsynaptic potential] GO:1901214 [regulation of neuron death] GO:1901215 [negative regulation of neuron death] GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1902499 [positive regulation of protein autoubiquitination] GO:1902692 [regulation of neuroblast proliferation] GO:1902803 [regulation of synaptic vesicle transport] GO:1902823 [negative regulation of late endosome to lysosome transport] GO:1903125 [negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation] GO:1903206 [negative regulation of hydrogen peroxide-induced cell death] GO:1903215 [negative regulation of protein targeting to mitochondrion] GO:1903217 [negative regulation of protein processing involved in protein targeting to mitochondrion] GO:1903351 [cellular response to dopamine] GO:1904713 [beta-catenin destruction complex binding] GO:2000172 [regulation of branching morphogenesis of a nerve] GO:2000300 [regulation of synaptic vesicle exocytosis] GO:2000469 [negative regulation of peroxidase activity]