We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
A few cases of hepatocellular carcinomas and single cases of renal and thyroid carcinomas were moderately cytoplasmic stained. Remaining cancer tissues were negative.
Cancer tissues showed moderate to strong cytoplasmic and membranous staining.
GENE INFORMATION
Gene name
LRRK2 (HGNC Symbol)
Synonyms
DKFZp434H2111, FLJ45829, PARK8, RIPK7, ROCO2
Description
Leucine-rich repeat kinase 2 (HGNC Symbol)
Entrez gene summary
This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]
SCAMPI predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases Kinases TKL Ser/Thr protein kinases SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149 [SNARE binding] GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0000187 [activation of MAPK activity] GO:0001933 [negative regulation of protein phosphorylation] GO:0001934 [positive regulation of protein phosphorylation] GO:0001948 [glycoprotein binding] GO:0003779 [actin binding] GO:0003924 [GTPase activity] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004708 [MAP kinase kinase activity] GO:0005096 [GTPase activator activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005525 [GTP binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005743 [mitochondrial inner membrane] GO:0005759 [mitochondrial matrix] GO:0005764 [lysosome] GO:0005768 [endosome] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005798 [Golgi-associated vesicle] GO:0005802 [trans-Golgi network] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006897 [endocytosis] GO:0006914 [autophagy] GO:0006979 [response to oxidative stress] GO:0007005 [mitochondrion organization] GO:0007030 [Golgi organization] GO:0007040 [lysosome organization] GO:0007264 [small GTPase mediated signal transduction] GO:0007528 [neuromuscular junction development] GO:0008021 [synaptic vesicle] GO:0008340 [determination of adult lifespan] GO:0010508 [positive regulation of autophagy] GO:0010738 [regulation of protein kinase A signaling] GO:0010955 [negative regulation of protein processing] GO:0014041 [regulation of neuron maturation] GO:0015031 [protein transport] GO:0015631 [tubulin binding] GO:0016020 [membrane] GO:0016234 [inclusion body] GO:0016301 [kinase activity] GO:0017048 [Rho GTPase binding] GO:0017075 [syntaxin-1 binding] GO:0018105 [peptidyl-serine phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0019722 [calcium-mediated signaling] GO:0021772 [olfactory bulb development] GO:0022028 [tangential migration from the subventricular zone to the olfactory bulb] GO:0030054 [cell junction] GO:0030159 [receptor signaling complex scaffold activity] GO:0030276 [clathrin binding] GO:0030424 [axon] GO:0030425 [dendrite] GO:0030426 [growth cone] GO:0030529 [ribonucleoprotein complex] GO:0030672 [synaptic vesicle membrane] GO:0031398 [positive regulation of protein ubiquitination] GO:0031410 [cytoplasmic vesicle] GO:0031966 [mitochondrial membrane] GO:0032091 [negative regulation of protein binding] GO:0032092 [positive regulation of protein binding] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032473 [cytoplasmic side of mitochondrial outer membrane] GO:0032839 [dendrite cytoplasm] GO:0034211 [GTP-dependent protein kinase activity] GO:0034260 [negative regulation of GTPase activity] GO:0034599 [cellular response to oxidative stress] GO:0034613 [cellular protein localization] GO:0035556 [intracellular signal transduction] GO:0035564 [regulation of kidney size] GO:0035640 [exploration behavior] GO:0035641 [locomotory exploration behavior] GO:0036479 [peroxidase inhibitor activity] GO:0040012 [regulation of locomotion] GO:0042391 [regulation of membrane potential] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043005 [neuron projection] GO:0043025 [neuronal cell body] GO:0043068 [positive regulation of programmed cell death] GO:0043195 [terminal bouton] GO:0043204 [perikaryon] GO:0043231 [intracellular membrane-bounded organelle] GO:0043406 [positive regulation of MAP kinase activity] GO:0043547 [positive regulation of GTPase activity] GO:0044325 [ion channel binding] GO:0045121 [membrane raft] GO:0045202 [synapse] GO:0046039 [GTP metabolic process] GO:0046777 [protein autophosphorylation] GO:0048312 [intracellular distribution of mitochondria] GO:0048812 [neuron projection morphogenesis] GO:0051018 [protein kinase A binding] GO:0051646 [mitochondrion localization] GO:0051900 [regulation of mitochondrial depolarization] GO:0051966 [regulation of synaptic transmission, glutamatergic] GO:0060079 [excitatory postsynaptic potential] GO:0060159 [regulation of dopamine receptor signaling pathway] GO:0060161 [positive regulation of dopamine receptor signaling pathway] GO:0060828 [regulation of canonical Wnt signaling pathway] GO:0061001 [regulation of dendritic spine morphogenesis] GO:0070062 [extracellular exosome] GO:0070585 [protein localization to mitochondrion] GO:0070997 [neuron death] GO:0071287 [cellular response to manganese ion] GO:0071407 [cellular response to organic cyclic compound] GO:0072593 [reactive oxygen species metabolic process] GO:0090140 [regulation of mitochondrial fission] GO:0090263 [positive regulation of canonical Wnt signaling pathway] GO:0090394 [negative regulation of excitatory postsynaptic potential] GO:1901214 [regulation of neuron death] GO:1901215 [negative regulation of neuron death] GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1902499 [positive regulation of protein autoubiquitination] GO:1902692 [regulation of neuroblast proliferation] GO:1902803 [regulation of synaptic vesicle transport] GO:1902823 [negative regulation of late endosome to lysosome transport] GO:1903125 [negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation] GO:1903206 [negative regulation of hydrogen peroxide-induced cell death] GO:1903215 [negative regulation of protein targeting to mitochondrion] GO:1903217 [negative regulation of protein processing involved in protein targeting to mitochondrion] GO:1903351 [cellular response to dopamine] GO:1904713 [beta-catenin destruction complex binding] GO:2000172 [regulation of branching morphogenesis of a nerve] GO:2000300 [regulation of synaptic vesicle exocytosis] GO:2000469 [negative regulation of peroxidase activity]