Expression of SBSN in cancer - Summary - The Human Protein Atlas

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SBSN

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SBSN
Gene description	Suprabasin
Protein class	Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (cervical cancer, head and neck cancer, melanoma)
HPA (cell line):	Cell line enhanced (ASC TERT1, U-2197, U-87 MG)
HPA (normal tissue):	Group enriched (esophagus, skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective membranous expression in squamous epithelia.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA062568 , HPA067734
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (cervical cancer, head and neck cancer, melanoma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA062568	HPA067734

GENE INFORMATION
Gene name	SBSN (HGNC Symbol)
Synonyms	HLAR698, UNQ698
Description	Suprabasin (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	q13.12
Chromosome location (bp)	35523367 - 35528351
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000189001 (version 83.38)
Entrez gene	374897
UniProt	Q6UWP8 (UniProt - Evidence at protein level)
neXtProt	NX_Q6UWP8
Antibodypedia	SBSN antibodies

PROTEIN BROWSER

SBSN-001	SBSN-002	SBSN-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SBSN-001 ENSP00000428771 ENST00000518157	Q6UWP8 [Direct mapping] Suprabasin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0008150 [biological_process] GO:0070062 [extracellular exosome] Show all	247 aa 25.3 kDa	Yes	0
SBSN-002 ENSP00000430242 ENST00000452271	Q6UWP8 [Direct mapping] Suprabasin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005737 [cytoplasm] GO:0008150 [biological_process] GO:0070062 [extracellular exosome] Show all	590 aa 60.5 kDa	Yes	0
SBSN-003 ENSP00000468646 ENST00000588674	K7ESC4 [Direct mapping] Suprabasin Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		149 aa 15.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.