Cell atlas - ALKBH2 - The Human Protein Atlas

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ALKBH2

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ALKBH2
Gene description	AlkB homolog 2, alpha-ketoglutarate-dependent dioxygenase
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (validated)

DATA RELIABILITY
Reliability score	Validated based on 3 antibodies. CAB011198 , HPA045392 , HPA051976
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus.

Main location

Nucleus (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	CAB011198	A-431	Nucleus
	CAB011198	A-431	Cytosol
	CAB011198	U-2 OS	Nucleus
	CAB011198	U-2 OS	Cytosol
	HPA045392	HEK 293	Nucleoplasm
	HPA045392	MCF7	Nucleoplasm
	HPA045392	MCF7	Microtubules
	HPA045392	U-2 OS	Nucleoplasm
	HPA051976	HEK 293	Nucleus
	HPA051976	MCF7	Nucleus
	HPA051976	U-2 OS	No staining

GENE INFORMATION
Gene name	ALKBH2 (HGNC Symbol)
Synonyms	ABH2, MGC90512
Description	AlkB homolog 2, alpha-ketoglutarate-dependent dioxygenase (HGNC Symbol)
Entrez gene summary	The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 (MIM 610603) are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]
Chromosome	12
Cytoband	q24.11
Chromosome location (bp)	109088188 - 109093631
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000189046 (version 83.38)
Entrez gene	121642
UniProt	Q6NS38 (UniProt - Evidence at protein level)
neXtProt	NX_Q6NS38
Antibodypedia	ALKBH2 antibodies

PROTEIN BROWSER

ALKBH2-001	ALKBH2-003	ALKBH2-005	ALKBH2-007	ALKBH2-008	ALKBH2-009	ALKBH2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ALKBH2-001 ENSP00000343021 ENST00000343075	Q6NS38 [Direct mapping] Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006281 [DNA repair] GO:0006307 [DNA dealkylation involved in DNA repair] GO:0008198 [ferrous iron binding] GO:0015630 [microtubule cytoskeleton] GO:0016491 [oxidoreductase activity] GO:0035511 [oxidative DNA demethylation] GO:0043734 [DNA-N1-methyladenine dioxygenase activity] GO:0051747 [cytosine C-5 DNA demethylase activity] GO:0055114 [oxidation-reduction process] GO:0070989 [oxidative demethylation] GO:0080111 [DNA demethylation] Show all	261 aa 29.3 kDa	No	0
ALKBH2-003 ENSP00000399820 ENST00000440112	Q6NS38 [Direct mapping] Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006281 [DNA repair] GO:0006307 [DNA dealkylation involved in DNA repair] GO:0008198 [ferrous iron binding] GO:0015630 [microtubule cytoskeleton] GO:0035511 [oxidative DNA demethylation] GO:0043734 [DNA-N1-methyladenine dioxygenase activity] GO:0051747 [cytosine C-5 DNA demethylase activity] GO:0070989 [oxidative demethylation] GO:0080111 [DNA demethylation] Show all	157 aa 17.1 kDa	No	0
ALKBH2-005 ENSP00000443042 ENST00000536242	F5H5X2 [Direct mapping] Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] Show all	150 aa 16.6 kDa	No	0
ALKBH2-007 ENSP00000398181 ENST00000429722	Q6NS38 [Direct mapping] Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006281 [DNA repair] GO:0006307 [DNA dealkylation involved in DNA repair] GO:0008198 [ferrous iron binding] GO:0015630 [microtubule cytoskeleton] GO:0016491 [oxidoreductase activity] GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors] GO:0035511 [oxidative DNA demethylation] GO:0043734 [DNA-N1-methyladenine dioxygenase activity] GO:0051747 [cytosine C-5 DNA demethylase activity] GO:0055114 [oxidation-reduction process] GO:0070989 [oxidative demethylation] GO:0080111 [DNA demethylation] Show all	261 aa 29.3 kDa	No	0
ALKBH2-008 ENSP00000444103 ENST00000536358	F5GZZ0 [Direct mapping] Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] Show all	121 aa 13.4 kDa	No	0
ALKBH2-009 ENSP00000474702 ENST00000543444	S4R3T5 [Direct mapping] Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		149 aa 16.6 kDa	No	0
ALKBH2-201 ENSP00000478765 ENST00000619381	Q6NS38 [Direct mapping] Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006281 [DNA repair] GO:0006307 [DNA dealkylation involved in DNA repair] GO:0008198 [ferrous iron binding] GO:0015630 [microtubule cytoskeleton] GO:0035511 [oxidative DNA demethylation] GO:0043734 [DNA-N1-methyladenine dioxygenase activity] GO:0051747 [cytosine C-5 DNA demethylase activity] GO:0070989 [oxidative demethylation] GO:0080111 [DNA demethylation] Show all	157 aa 17.1 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.