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ALKBH2

GENERAL INFORMATION

Gene name

 ALKBH2

Gene description

 AlkB homolog 2, alpha-ketoglutarate-dependent dioxygenase

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB011198
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), breast cancer (favourable) and urothelial cancer (favourable).
Renal cancer p<0.001
Breast cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB011198

GENE INFORMATION

Gene name

 ALKBH2 (HGNC Symbol)

Synonyms

 ABH2, MGC90512

Description

 AlkB homolog 2, alpha-ketoglutarate-dependent dioxygenase (HGNC Symbol)

Entrez gene summary

 The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 (MIM 610603) are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]

Chromosome

 12

Cytoband

 q24.11

Chromosome location (bp)

 109088188 - 109093631

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000189046 (version 83.38)

Entrez gene

 121642

UniProt

 Q6NS38 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6NS38

Antibodypedia

 ALKBH2 antibodies

PROTEIN BROWSER
ALKBH2-001
ALKBH2-003
ALKBH2-005
ALKBH2-007
ALKBH2-008
ALKBH2-009
ALKBH2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ALKBH2-001
ENSP00000343021
ENST00000343075
Q6NS38 [Direct mapping]
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006307 [DNA dealkylation involved in DNA repair]
GO:0008198 [ferrous iron binding]
GO:0015630 [microtubule cytoskeleton]
GO:0016491 [oxidoreductase activity]
GO:0035511 [oxidative DNA demethylation]
GO:0043734 [DNA-N1-methyladenine dioxygenase activity]
GO:0051747 [cytosine C-5 DNA demethylase activity]
GO:0055114 [oxidation-reduction process]
GO:0070989 [oxidative demethylation]
GO:0080111 [DNA demethylation]
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 261 aa
29.3 kDa 		No 0
ALKBH2-003
ENSP00000399820
ENST00000440112
Q6NS38 [Direct mapping]
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006307 [DNA dealkylation involved in DNA repair]
GO:0008198 [ferrous iron binding]
GO:0015630 [microtubule cytoskeleton]
GO:0035511 [oxidative DNA demethylation]
GO:0043734 [DNA-N1-methyladenine dioxygenase activity]
GO:0051747 [cytosine C-5 DNA demethylase activity]
GO:0070989 [oxidative demethylation]
GO:0080111 [DNA demethylation]
Show all
 157 aa
17.1 kDa 		No 0
ALKBH2-005
ENSP00000443042
ENST00000536242
F5H5X2 [Direct mapping]
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
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 150 aa
16.6 kDa 		No 0
ALKBH2-007
ENSP00000398181
ENST00000429722
Q6NS38 [Direct mapping]
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006307 [DNA dealkylation involved in DNA repair]
GO:0008198 [ferrous iron binding]
GO:0015630 [microtubule cytoskeleton]
GO:0016491 [oxidoreductase activity]
GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors]
GO:0035511 [oxidative DNA demethylation]
GO:0043734 [DNA-N1-methyladenine dioxygenase activity]
GO:0051747 [cytosine C-5 DNA demethylase activity]
GO:0055114 [oxidation-reduction process]
GO:0070989 [oxidative demethylation]
GO:0080111 [DNA demethylation]
Show all
 261 aa
29.3 kDa 		No 0
ALKBH2-008
ENSP00000444103
ENST00000536358
F5GZZ0 [Direct mapping]
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
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 121 aa
13.4 kDa 		No 0
ALKBH2-009
ENSP00000474702
ENST00000543444
S4R3T5 [Direct mapping]
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 149 aa
16.6 kDa 		No 0
ALKBH2-201
ENSP00000478765
ENST00000619381
Q6NS38 [Direct mapping]
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006307 [DNA dealkylation involved in DNA repair]
GO:0008198 [ferrous iron binding]
GO:0015630 [microtubule cytoskeleton]
GO:0035511 [oxidative DNA demethylation]
GO:0043734 [DNA-N1-methyladenine dioxygenase activity]
GO:0051747 [cytosine C-5 DNA demethylase activity]
GO:0070989 [oxidative demethylation]
GO:0080111 [DNA demethylation]
Show all
 157 aa
17.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.