Cell atlas - SP6 - The Human Protein Atlas

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SP6

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS CELL CYCLE

GENE/PROTEIN

Antibody validation

Dictionary
	Centrosome
	Mitotic spindle
	Nucleoplasm

Human cell
	Centrosome
	Microtubules
	Nucleoplasm

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GENERAL INFORMATION
Gene name	SP6
Gene description	Sp6 transcription factor
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the centrosome & mitotic spindle.
RNA cell category	Cell line enriched (BEWO)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)
Additional location	In addition localized to the Mitotic spindle (approved), Centrosome (approved)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by biological definition

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA024516 , HPA044469
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (BEWO) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the centrosome & mitotic spindle.

Main location

Nucleoplasm (supported)

Additional location

Mitotic spindle (approved), Centrosome (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
HPA024516	CACO-2	Nucleoplasm
HPA024516	RT4	Nucleoplasm
HPA024516	U-2 OS	Nucleoplasm
HPA044469	CACO-2	Nucleoplasm
		Mitotic spindle	Intensity	Intensity
		Centrosome
HPA044469	RT4	Nucleoplasm
HPA044469	RT4	Centrosome

CELL CYCLE
Summary	Expression has cell cycle dependency according to biological definition
Intensity variation	Mitotic spindle

GENE INFORMATION
Gene name	SP6 (HGNC Symbol)
Synonyms	Epfn, KLF14
Description	Sp6 transcription factor (HGNC Symbol)
Entrez gene summary	SP6 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 [PubMed 11087666]).[supplied by OMIM, Mar 2008]
Chromosome	17
Cytoband	q21.32
Chromosome location (bp)	47844908 - 47855874
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000189120 (version 83.38)
Entrez gene	80320
UniProt	Q3SY56 (UniProt - Evidence at transcript level)
neXtProt	NX_Q3SY56
Antibodypedia	SP6 antibodies

PROTEIN BROWSER

SP6-001	SP6-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SP6-001 ENSP00000340799 ENST00000342234	Q3SY56 [Direct mapping] Transcription factor Sp6 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	376 aa 39.8 kDa	No	0
SP6-002 ENSP00000438209 ENST00000536300	Q3SY56 [Direct mapping] Transcription factor Sp6 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008284 [positive regulation of cell proliferation] GO:0042481 [regulation of odontogenesis] GO:0046872 [metal ion binding] Show all	376 aa 39.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.