Expression of SP6 in cancer - Summary - The Human Protein Atlas

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SP6

TISSUE

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CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	SP6
Gene description	Sp6 transcription factor
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enriched (BEWO)
HPA (normal tissue):	Tissue enhanced (placenta, seminal vesicle)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (unfavourable), urothelial cancer (favourable) and stomach cancer (favourable).
Lung cancer p<0.001 Urothelial cancer p<0.001 Stomach cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	SP6 (HGNC Symbol)
Synonyms	Epfn, KLF14
Description	Sp6 transcription factor (HGNC Symbol)
Entrez gene summary	SP6 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 [PubMed 11087666]).[supplied by OMIM, Mar 2008]
Chromosome	17
Cytoband	q21.32
Chromosome location (bp)	47844908 - 47855874
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000189120 (version 83.38)
Entrez gene	80320
UniProt	Q3SY56 (UniProt - Evidence at transcript level)
neXtProt	NX_Q3SY56
Antibodypedia	SP6 antibodies

PROTEIN BROWSER

SP6-001	SP6-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SP6-001 ENSP00000340799 ENST00000342234	Q3SY56 [Direct mapping] Transcription factor Sp6 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	376 aa 39.8 kDa	No	0
SP6-002 ENSP00000438209 ENST00000536300	Q3SY56 [Direct mapping] Transcription factor Sp6 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008284 [positive regulation of cell proliferation] GO:0042481 [regulation of odontogenesis] GO:0046872 [metal ion binding] Show all	376 aa 39.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.