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A majority of adenocarcinomas and some squamous cell carcinomas showed moderate to strong cytoplasmic and membranous immunoreactivity. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
CLDN4 (HGNC Symbol)
Synonyms
CPE-R, CPETR, CPETR1, hCPE-R, WBSCR8
Description
Claudin 4 (HGNC Symbol)
Entrez gene summary
The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Sep 2013]