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CLDN4

GENERAL INFORMATION

Gene name

 CLDN4

Gene description

 Claudin 4

Protein class

 Cancer-related genes
Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Tissue enhanced (thyroid gland)

Protein evidence

 Evidence at protein level

Protein expression

 Membranous expression in several tissues, most abundant in gastrointestinal tract.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
CAB002610
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Esophagus

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (thyroid gland)

GENE INFORMATION

Gene name

 CLDN4 (HGNC Symbol)

Synonyms

 CPE-R, CPETR, CPETR1, hCPE-R, WBSCR8

Description

 Claudin 4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Sep 2013]

Chromosome

 7

Cytoband

 q11.23

Chromosome location (bp)

 73799542 - 73832693

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000189143 (version 83.38)

Entrez gene

 1364

UniProt

 O14493 (UniProt - Evidence at protein level)

neXtProt

 NX_O14493

Antibodypedia

 CLDN4 antibodies

PROTEIN BROWSER
CLDN4-001
CLDN4-002
CLDN4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CLDN4-001
ENSP00000388639
ENST00000431918
O14493 [Direct mapping]
Claudin-4
Q75L80 [Target identity:100%; Query identity:100%]
Claudin
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Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0005198 [structural molecule activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005923 [bicellular tight junction]
GO:0007165 [signal transduction]
GO:0016021 [integral component of membrane]
GO:0016338 [calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules]
GO:0042802 [identical protein binding]
GO:0061436 [establishment of skin barrier]
Show all
 209 aa
22.1 kDa 		No 3
CLDN4-002
ENSP00000409544
ENST00000435050
O14493 [Direct mapping]
Claudin-4
Q75L80 [Target identity:100%; Query identity:100%]
Claudin
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005923 [bicellular tight junction]
GO:0007165 [signal transduction]
GO:0007565 [female pregnancy]
GO:0007623 [circadian rhythm]
GO:0009925 [basal plasma membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0016327 [apicolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016338 [calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules]
GO:0032570 [response to progesterone]
GO:0042802 [identical protein binding]
GO:0061436 [establishment of skin barrier]
Show all
 209 aa
22.1 kDa 		No 3
CLDN4-201
ENSP00000342445
ENST00000340958
O14493 [Direct mapping]
Claudin-4
Q75L80 [Target identity:100%; Query identity:100%]
Claudin
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0005198 [structural molecule activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005923 [bicellular tight junction]
GO:0007165 [signal transduction]
GO:0016021 [integral component of membrane]
GO:0016338 [calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules]
GO:0042802 [identical protein binding]
GO:0061436 [establishment of skin barrier]
Show all
 209 aa
22.1 kDa 		No 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.