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MAOA

GENERAL INFORMATION

Gene name

 MAOA

Gene description

 Monoamine oxidase A

Protein class

 Disease related genes
Enzymes
FDA approved drug targets
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (hTCEpi, RT4)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression with a granular pattern in all tissies.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA054807 , HPA059299 , CAB009437
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA054807
HPA059299
CAB009437

GENE INFORMATION

Gene name

 MAOA

Synonyms

Description

 Monoamine oxidase A (HGNC Symbol)

Entrez gene summary

 This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]

Chromosome

 X

Cytoband

 p11.3

Chromosome location (bp)

 43654907 - 43746824

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000189221 (version 83.38)

Entrez gene

 4128

UniProt

 P21397 (UniProt - Evidence at protein level)

neXtProt

 NX_P21397

Antibodypedia

 MAOA antibodies

PROTEIN BROWSER
MAOA-001
MAOA-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAOA-001
ENSP00000340684
ENST00000338702
P21397 [Direct mapping]
Amine oxidase [flavin-containing] A
Q53YE7 [Target identity:100%; Query identity:100%]
Amine oxidase [flavin-containing]
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0006576 [cellular biogenic amine metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0008131 [primary amine oxidase activity]
GO:0016021 [integral component of membrane]
GO:0016491 [oxidoreductase activity]
GO:0042135 [neurotransmitter catabolic process]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0042420 [dopamine catabolic process]
GO:0042428 [serotonin metabolic process]
GO:0042443 [phenylethylamine metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0051378 [serotonin binding]
GO:0055114 [oxidation-reduction process]
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 527 aa
59.7 kDa 		No 1
MAOA-201
ENSP00000440846
ENST00000542639
P21397 [Direct mapping]
Amine oxidase [flavin-containing] A
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0006576 [cellular biogenic amine metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0008131 [primary amine oxidase activity]
GO:0016021 [integral component of membrane]
GO:0016491 [oxidoreductase activity]
GO:0042135 [neurotransmitter catabolic process]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0042420 [dopamine catabolic process]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
Show all
 394 aa
44.8 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.