Expression of GJB5 in cancer - Summary - The Human Protein Atlas

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GJB5

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GJB5
Gene description	Gap junction protein, beta 5, 31.1kDa
Protein class	Cancer-related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (cervical cancer, head and neck cancer, lung cancer, urothelial cancer)
HPA (cell line):	Group enriched (A-431, HaCaT, hTCEpi, RT4)
HPA (normal tissue):	Group enriched (esophagus, skin)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA038146
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (cervical cancer, head and neck cancer, lung cancer, urothelial cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038146

GENE INFORMATION
Gene name	GJB5 (HGNC Symbol)
Synonyms	CX31.1
Description	Gap junction protein, beta 5, 31.1kDa (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the beta-type (group I) connexin family. The encoded protein is a gap junction protein involved in intercellular communication related to epidermal differentiation and environmental sensing. This gene has been linked to non-small cell lung cancer. [provided by RefSeq, Nov 2012]
Chromosome	1
Cytoband	p34.3
Chromosome location (bp)	34755047 - 34758512
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000189280 (version 83.38)
Entrez gene	2709
UniProt	O95377 (UniProt - Evidence at transcript level)
neXtProt	NX_O95377
Antibodypedia	GJB5 antibodies

PROTEIN BROWSER

GJB5-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GJB5-001 ENSP00000340811 ENST00000338513	O95377 [Direct mapping] Gap junction beta-5 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Show all	GO:0005922 [connexon complex] GO:0007154 [cell communication] GO:0008544 [epidermis development] GO:0016021 [integral component of membrane] GO:0060707 [trophoblast giant cell differentiation] GO:0060708 [spongiotrophoblast differentiation] GO:0060713 [labyrinthine layer morphogenesis] Show all	273 aa 31.1 kDa	No	4

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.