Tissue expression of GJB5 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	GJB5
Gene description	Gap junction protein, beta 5, 31.1kDa
Protein class	Cancer-related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (esophagus, skin)
GTEx:	Group enriched (esophagus, skin, vagina)
FANTOM5:	Tissue enhanced (esophagus, tonsil)

Protein evidence

Evidence at transcript level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA038146
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (esophagus, skin)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (esophagus, skin, vagina)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (esophagus, tonsil)

GENE INFORMATION
Gene name	GJB5 (HGNC Symbol)
Synonyms	CX31.1
Description	Gap junction protein, beta 5, 31.1kDa (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the beta-type (group I) connexin family. The encoded protein is a gap junction protein involved in intercellular communication related to epidermal differentiation and environmental sensing. This gene has been linked to non-small cell lung cancer. [provided by RefSeq, Nov 2012]
Chromosome	1
Cytoband	p34.3
Chromosome location (bp)	34755047 - 34758512
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000189280 (version 83.38)
Entrez gene	2709
UniProt	O95377 (UniProt - Evidence at transcript level)
neXtProt	NX_O95377
Antibodypedia	GJB5 antibodies

PROTEIN BROWSER

GJB5-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GJB5-001 ENSP00000340811 ENST00000338513	O95377 [Direct mapping] Gap junction beta-5 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Show all	GO:0005922 [connexon complex] GO:0007154 [cell communication] GO:0008544 [epidermis development] GO:0016021 [integral component of membrane] GO:0060707 [trophoblast giant cell differentiation] GO:0060708 [spongiotrophoblast differentiation] GO:0060713 [labyrinthine layer morphogenesis] Show all	273 aa 31.1 kDa	No	4