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S100A14

GENERAL INFORMATION

Gene name

 S100A14

Gene description

 S100 calcium binding protein A14

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Group enriched (A-431, HaCaT, hTCEpi, SK-BR-3)
HPA (normal tissue):Tissue enhanced (esophagus)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Expression in squamous epithelial cells with additional membranous staining in some tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA027613
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA027613

GENE INFORMATION

Gene name

 S100A14 (HGNC Symbol)

Synonyms

 BCMP84, S100A15

Description

 S100 calcium binding protein A14 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the S100 protein family which contains an EF-hand motif and binds calcium. The gene is located in a cluster of S100 genes on chromosome 1. Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function (PMID: 19956863, 19351828). [provided by RefSeq, Dec 2011]

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 153614255 - 153616986

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000189334 (version 83.38)

Entrez gene

 57402

UniProt

 Q9HCY8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HCY8

Antibodypedia

 S100A14 antibodies

PROTEIN BROWSER
S100A14-001
S100A14-002
S100A14-003
S100A14-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
S100A14-001
ENSP00000420296
ENST00000476873
Q9HCY8 [Direct mapping]
Protein S100-A14
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0015630 [microtubule cytoskeleton]
GO:0030054 [cell junction]
GO:0032496 [response to lipopolysaccharide]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0042379 [chemokine receptor binding]
GO:0042742 [defense response to bacterium]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055074 [calcium ion homeostasis]
GO:0070062 [extracellular exosome]
GO:0071624 [positive regulation of granulocyte chemotaxis]
GO:0090026 [positive regulation of monocyte chemotaxis]
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 104 aa
11.7 kDa 		No 0
S100A14-002
ENSP00000357690
ENST00000368701
Q9HCY8 [Direct mapping]
Protein S100-A14
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0015630 [microtubule cytoskeleton]
GO:0030054 [cell junction]
GO:0032496 [response to lipopolysaccharide]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0042379 [chemokine receptor binding]
GO:0042742 [defense response to bacterium]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055074 [calcium ion homeostasis]
GO:0070062 [extracellular exosome]
GO:0071624 [positive regulation of granulocyte chemotaxis]
GO:0090026 [positive regulation of monocyte chemotaxis]
Show all
 104 aa
11.7 kDa 		No 0
S100A14-003
ENSP00000357691
ENST00000368702
Q9HCY8 [Direct mapping]
Protein S100-A14
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0015630 [microtubule cytoskeleton]
GO:0030054 [cell junction]
GO:0032496 [response to lipopolysaccharide]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0042379 [chemokine receptor binding]
GO:0042742 [defense response to bacterium]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055074 [calcium ion homeostasis]
GO:0070062 [extracellular exosome]
GO:0071624 [positive regulation of granulocyte chemotaxis]
GO:0090026 [positive regulation of monocyte chemotaxis]
Show all
 104 aa
11.7 kDa 		No 0
S100A14-201
ENSP00000340463
ENST00000344616
Q9HCY8 [Direct mapping]
Protein S100-A14
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0015630 [microtubule cytoskeleton]
GO:0030054 [cell junction]
GO:0032496 [response to lipopolysaccharide]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0042379 [chemokine receptor binding]
GO:0042742 [defense response to bacterium]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055074 [calcium ion homeostasis]
GO:0070062 [extracellular exosome]
GO:0071624 [positive regulation of granulocyte chemotaxis]
GO:0090026 [positive regulation of monocyte chemotaxis]
Show all
 104 aa
11.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.