Expression of CCDC189 in cancer - Summary - The Human Protein Atlas

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CCDC189

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CCDC189
Gene description	Coiled-coil domain containing 189
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enhanced (fallopian tube)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several different cell types. High expression in cilia.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA041806 , HPA046289
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041806	HPA046289

GENE INFORMATION
Gene name	CCDC189 (HGNC Symbol)
Synonyms	C16orf93, MGC104706
Description	Coiled-coil domain containing 189 (HGNC Symbol)
Entrez gene summary
Chromosome	16
Cytoband	p11.2
Chromosome location (bp)	30757423 - 30762710
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196118 (version 83.38)
Entrez gene	90835
UniProt	A1A4V9 (UniProt - Evidence at transcript level)
neXtProt	NX_A1A4V9
Antibodypedia	CCDC189 antibodies

PROTEIN BROWSER

CCDC189-003	CCDC189-005	CCDC189-006	CCDC189-011	CCDC189-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCDC189-003 ENSP00000437532 ENST00000543610	A1A4V9 [Direct mapping] Coiled-coil domain-containing protein C16orf93 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all		331 aa 37.9 kDa	No	0
CCDC189-005 ENSP00000457287 ENST00000541260	H3BTQ9 [Direct mapping] Coiled-coil domain-containing protein C16orf93 Show all	Predicted intracellular proteins Show all		396 aa 44.8 kDa	No	0
CCDC189-006 ENSP00000441164 ENST00000545825	A1A4V9 [Direct mapping] Coiled-coil domain-containing protein C16orf93 Show all	Predicted intracellular proteins Show all		177 aa 20 kDa	No	0
CCDC189-011 ENSP00000442644 ENST00000535476	H0YGC5 [Direct mapping] Coiled-coil domain-containing protein C16orf93 Show all	Predicted intracellular proteins Show all		145 aa 16.9 kDa	No	0
CCDC189-012 ENSP00000455034 ENST00000544613	H3BNW1 [Direct mapping] Coiled-coil domain-containing protein C16orf93 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all		91 aa 9.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.