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TUBB

GENERAL INFORMATION

Gene name

 TUBB

Gene description

 Tubulin, beta class I

Protein class

 Disease related genes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression at variable levels in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. External characterization data supports antibody staining.

Reliability score

 Supported based on 4 antibodies.
HPA043640 , HPA046280 , CAB005417 , CAB012406
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA043640
HPA046280
CAB005417
CAB012406

GENE INFORMATION

Gene name

 TUBB (HGNC Symbol)

Synonyms

 M40, MGC16435, OK/SW-cl.56, Tubb5

Description

 Tubulin, beta class I (HGNC Symbol)

Entrez gene summary

 This gene encodes a beta tubulin protein. This protein forms a dimer with alpha tubulin and acts as a structural component of microtubules. Mutations in this gene cause cortical dysplasia, complex, with other brain malformations 6. Alternative splicing results in multiple splice variants. There are multiple pseudogenes for this gene on chromosomes 1, 6, 7, 8, 9, and 13. [provided by RefSeq, Jun 2014]

Chromosome

 6

Cytoband

 p21.33

Chromosome location (bp)

 30720201 - 30725426

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196230 (version 83.38)

Entrez gene

 203068

UniProt

 P07437 (UniProt - Evidence at protein level)

neXtProt

 NX_P07437

Antibodypedia

 TUBB antibodies

PROTEIN BROWSER
TUBB-001
TUBB-002
TUBB-003
TUBB-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TUBB-001
ENSP00000339001
ENST00000327892
P07437 [Direct mapping]
Tubulin beta chain
Q5SU16 [Target identity:100%; Query identity:100%]
Beta 5-tubulin; Beta-tubulin protein; Tubulin, beta; Tubulin, beta, isoform CRA_a
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0003924 [GTPase activity]
GO:0005198 [structural molecule activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005641 [nuclear envelope lumen]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0006928 [movement of cell or subcellular component]
GO:0006996 [organelle organization]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
GO:0009987 [cellular process]
GO:0019904 [protein domain specific binding]
GO:0030705 [cytoskeleton-dependent intracellular transport]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032403 [protein complex binding]
GO:0032794 [GTPase activating protein binding]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0042267 [natural killer cell mediated cytotoxicity]
GO:0042288 [MHC class I protein binding]
GO:0043234 [protein complex]
GO:0044297 [cell body]
GO:0051225 [spindle assembly]
GO:0051258 [protein polymerization]
GO:0051301 [cell division]
GO:0070062 [extracellular exosome]
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 444 aa
49.7 kDa 		No 0
TUBB-002
ENSP00000365578
ENST00000330914
Q5ST81 [Direct mapping]
Tubulin beta chain
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
GO:0043234 [protein complex]
GO:0051258 [protein polymerization]
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 372 aa
41.7 kDa 		No 0
TUBB-003
ENSP00000379672
ENST00000396389
Q5JP53 [Direct mapping]
Tubulin beta chain
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
GO:0043234 [protein complex]
GO:0051258 [protein polymerization]
Show all
 426 aa
47.8 kDa 		No 0
TUBB-004
ENSP00000379668
ENST00000396384
Q5ST81 [Direct mapping]
Tubulin beta chain
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
GO:0043234 [protein complex]
GO:0051258 [protein polymerization]
Show all
 372 aa
41.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.