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ATP2A1

GENERAL INFORMATION

Gene name

 ATP2A1

Gene description

 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (head and neck cancer)
HPA (cell line):Mixed
HPA (normal tissue):Tissue enriched (skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in skeletal muscle.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
CAB032706
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (head and neck cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB032706

GENE INFORMATION

Gene name

 ATP2A1 (HGNC Symbol)

Synonyms

 ATP2A, SERCA1

Description

 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Oct 2013]

Chromosome

 16

Cytoband

 p11.2

Chromosome location (bp)

 28878405 - 28904509

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196296 (version 83.38)

Entrez gene

 487

UniProt

 O14983 (UniProt - Evidence at protein level)

neXtProt

 NX_O14983

Antibodypedia

 ATP2A1 antibodies

PROTEIN BROWSER
ATP2A1-001
ATP2A1-002
ATP2A1-003
ATP2A1-007
ATP2A1-008
ATP2A1-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATP2A1-001
ENSP00000349595
ENST00000357084
O14983 [Direct mapping]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005388 [calcium-transporting ATPase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005887 [integral component of plasma membrane]
GO:0006816 [calcium ion transport]
GO:0006942 [regulation of striated muscle contraction]
GO:0007596 [blood coagulation]
GO:0008152 [metabolic process]
GO:0008637 [apoptotic mitochondrial changes]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016529 [sarcoplasmic reticulum]
GO:0031095 [platelet dense tubular network membrane]
GO:0031448 [positive regulation of fast-twitch skeletal muscle fiber contraction]
GO:0031673 [H zone]
GO:0031674 [I band]
GO:0032470 [positive regulation of endoplasmic reticulum calcium ion concentration]
GO:0032471 [negative regulation of endoplasmic reticulum calcium ion concentration]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0034220 [ion transmembrane transport]
GO:0034704 [calcium channel complex]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0042803 [protein homodimerization activity]
GO:0045988 [negative regulation of striated muscle contraction]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051561 [positive regulation of mitochondrial calcium ion concentration]
GO:0051659 [maintenance of mitochondrion location]
GO:0055085 [transmembrane transport]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0090076 [relaxation of skeletal muscle]
Show all
 1001 aa
110.3 kDa 		No >9
ATP2A1-002
ENSP00000378879
ENST00000395503
O14983 [Direct mapping]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005388 [calcium-transporting ATPase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005887 [integral component of plasma membrane]
GO:0006816 [calcium ion transport]
GO:0006942 [regulation of striated muscle contraction]
GO:0007596 [blood coagulation]
GO:0008152 [metabolic process]
GO:0008637 [apoptotic mitochondrial changes]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016529 [sarcoplasmic reticulum]
GO:0031095 [platelet dense tubular network membrane]
GO:0031448 [positive regulation of fast-twitch skeletal muscle fiber contraction]
GO:0031673 [H zone]
GO:0031674 [I band]
GO:0032470 [positive regulation of endoplasmic reticulum calcium ion concentration]
GO:0032471 [negative regulation of endoplasmic reticulum calcium ion concentration]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0034220 [ion transmembrane transport]
GO:0034704 [calcium channel complex]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0042803 [protein homodimerization activity]
GO:0045988 [negative regulation of striated muscle contraction]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051561 [positive regulation of mitochondrial calcium ion concentration]
GO:0051659 [maintenance of mitochondrion location]
GO:0055085 [transmembrane transport]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0090076 [relaxation of skeletal muscle]
Show all
 994 aa
109.3 kDa 		No >9
ATP2A1-003
ENSP00000443101
ENST00000536376
O14983 [Direct mapping]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005388 [calcium-transporting ATPase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005887 [integral component of plasma membrane]
GO:0006816 [calcium ion transport]
GO:0006942 [regulation of striated muscle contraction]
GO:0007596 [blood coagulation]
GO:0008152 [metabolic process]
GO:0008637 [apoptotic mitochondrial changes]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016529 [sarcoplasmic reticulum]
GO:0031095 [platelet dense tubular network membrane]
GO:0031448 [positive regulation of fast-twitch skeletal muscle fiber contraction]
GO:0031673 [H zone]
GO:0031674 [I band]
GO:0032470 [positive regulation of endoplasmic reticulum calcium ion concentration]
GO:0032471 [negative regulation of endoplasmic reticulum calcium ion concentration]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0034220 [ion transmembrane transport]
GO:0034704 [calcium channel complex]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0042803 [protein homodimerization activity]
GO:0045988 [negative regulation of striated muscle contraction]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051561 [positive regulation of mitochondrial calcium ion concentration]
GO:0051659 [maintenance of mitochondrion location]
GO:0055085 [transmembrane transport]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0090076 [relaxation of skeletal muscle]
Show all
 869 aa
95.2 kDa 		No 8
ATP2A1-007
ENSP00000458035
ENST00000563975
H3BVB2 [Direct mapping]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005388 [calcium-transporting ATPase activity]
GO:0005524 [ATP binding]
GO:0016021 [integral component of membrane]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0046872 [metal ion binding]
GO:0070588 [calcium ion transmembrane transport]
Show all
 114 aa
13.1 kDa 		No 2
ATP2A1-008
ENSP00000457798
ENST00000562185
H3BUU3 [Direct mapping]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0046872 [metal ion binding]
Show all
 26 aa
3 kDa 		No 0
ATP2A1-010
ENSP00000457793
ENST00000564112
H3BUT9 [Direct mapping]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 24 aa
2.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.