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POM121

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GENERAL INFORMATION

Gene name

 POM121

Gene description

 POM121 transmembrane nucleoporin

Protein class

 Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nuclear membrane & nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated), Nuclear membrane (validated)

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
CAB003710 , HPA049817
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nuclear membrane & nucleoplasm.

Main location

 Nucleoplasm (validated), Nuclear membrane (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB003710 A-431 Nucleoplasm
Nuclear membrane
CAB003710 U-2 OS Nucleoplasm
Nuclear membrane
CAB003710 U-251 MG Nucleoplasm
Nuclear membrane
HPA049817 A-431 Nucleoplasm
Nuclear membrane
HPA049817 HeLa Nucleoplasm
Nuclear membrane
HPA049817 U-2 OS Nucleoplasm
Nuclear membrane

GENE INFORMATION

Gene name

 POM121 (HGNC Symbol)

Synonyms

 DKFZP586G1822, DKFZP586P2220, KIAA0618, POM121A

Description

 POM121 transmembrane nucleoporin (HGNC Symbol)

Entrez gene summary

 This gene encodes a transmembrane protein that localizes to the inner nuclear membrane and forms a core component of the nuclear pore complex, which mediates transport to and from the nucleus. The encoded protein may anchor this complex to the nuclear envelope. There are multiple related genes and pseudogenes for this gene on chromosomes 5, 7, 15, and 22. Alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2013]

Chromosome

 7

Cytoband

 q11.23

Chromosome location (bp)

 72879365 - 72951440

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196313 (version 83.38)

Entrez gene

 9883

UniProt

 Q96HA1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96HA1

Antibodypedia

 POM121 antibodies

PROTEIN BROWSER
POM121-001
POM121-002
POM121-003
POM121-201
POM121-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
POM121-001
ENSP00000405562
ENST00000434423
Q96HA1 [Direct mapping]
Nuclear envelope pore membrane protein POM 121
Show all
Transporters
   Transporter channels and pores
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0005643 [nuclear pore]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0008033 [tRNA processing]
GO:0008645 [hexose transport]
GO:0010467 [gene expression]
GO:0010827 [regulation of glucose transport]
GO:0015031 [protein transport]
GO:0015758 [glucose transport]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031047 [gene silencing by RNA]
GO:0031965 [nuclear membrane]
GO:0034605 [cellular response to heat]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0051028 [mRNA transport]
GO:0055085 [transmembrane transport]
GO:1900034 [regulation of cellular response to heat]
Show all
 1249 aa
127.7 kDa 		No 0
POM121-002
ENSP00000351124
ENST00000358357
Q96HA1 [Direct mapping]
Nuclear envelope pore membrane protein POM 121
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0005643 [nuclear pore]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0008033 [tRNA processing]
GO:0008645 [hexose transport]
GO:0010467 [gene expression]
GO:0010827 [regulation of glucose transport]
GO:0015031 [protein transport]
GO:0015758 [glucose transport]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031047 [gene silencing by RNA]
GO:0031965 [nuclear membrane]
GO:0034605 [cellular response to heat]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0051028 [mRNA transport]
GO:0055085 [transmembrane transport]
GO:1900034 [regulation of cellular response to heat]
Show all
 984 aa
99 kDa 		No 0
POM121-003
ENSP00000378687
ENST00000395270
Q96HA1 [Direct mapping]
Nuclear envelope pore membrane protein POM 121
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0005643 [nuclear pore]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0008033 [tRNA processing]
GO:0008645 [hexose transport]
GO:0010467 [gene expression]
GO:0010827 [regulation of glucose transport]
GO:0015031 [protein transport]
GO:0015758 [glucose transport]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031047 [gene silencing by RNA]
GO:0031965 [nuclear membrane]
GO:0034605 [cellular response to heat]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0051028 [mRNA transport]
GO:0055085 [transmembrane transport]
GO:1900034 [regulation of cellular response to heat]
Show all
 999 aa
100.9 kDa 		No 0
POM121-201
ENSP00000393020
ENST00000446813
Q96HA1 [Direct mapping]
Nuclear envelope pore membrane protein POM 121
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0005643 [nuclear pore]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0008033 [tRNA processing]
GO:0008645 [hexose transport]
GO:0010467 [gene expression]
GO:0010827 [regulation of glucose transport]
GO:0015031 [protein transport]
GO:0015758 [glucose transport]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031047 [gene silencing by RNA]
GO:0031965 [nuclear membrane]
GO:0034605 [cellular response to heat]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0051028 [mRNA transport]
GO:0055085 [transmembrane transport]
GO:1900034 [regulation of cellular response to heat]
Show all
 999 aa
100.9 kDa 		No 0
POM121-202
ENSP00000486504
ENST00000627934
Q96HA1 [Direct mapping]
Nuclear envelope pore membrane protein POM 121
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0005643 [nuclear pore]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0008033 [tRNA processing]
GO:0008645 [hexose transport]
GO:0010467 [gene expression]
GO:0010827 [regulation of glucose transport]
GO:0015031 [protein transport]
GO:0015758 [glucose transport]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031047 [gene silencing by RNA]
GO:0031965 [nuclear membrane]
GO:0034605 [cellular response to heat]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0051028 [mRNA transport]
GO:0055085 [transmembrane transport]
GO:1900034 [regulation of cellular response to heat]
Show all
 984 aa
99 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.