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ELAVL3

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GENERAL INFORMATION

Gene name

 ELAVL3

Gene description

 ELAV like neuron-specific RNA binding protein 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to vesicles.

RNA cell category

 Group enriched (SCLC-21H, SH-SY5Y)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Vesicles (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA045610
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (SCLC-21H, SH-SY5Y)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to vesicles.

Main location

 Vesicles (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA045610 SH-SY5Y Vesicles Intensity
HPA045610 U-2 OS No staining    

GENE INFORMATION

Gene name

 ELAVL3 (HGNC Symbol)

Synonyms

 DKFZp547J036, HUC, HUCL, MGC20653, PLE21

Description

 ELAV like neuron-specific RNA binding protein 3 (HGNC Symbol)

Entrez gene summary

 A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 p13.2

Chromosome location (bp)

 11451326 - 11481046

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196361 (version 83.38)

Entrez gene

 1995

UniProt

 Q14576 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q14576

Antibodypedia

 ELAVL3 antibodies

PROTEIN BROWSER
ELAVL3-001
ELAVL3-002
ELAVL3-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ELAVL3-001
ENSP00000352162
ENST00000359227
Q14576 [Direct mapping]
ELAV-like protein 3
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0007399 [nervous system development]
GO:0017091 [AU-rich element binding]
GO:0030154 [cell differentiation]
Show all
 367 aa
39.5 kDa 		No 0
ELAVL3-002
ENSP00000390878
ENST00000438662
Q14576 [Direct mapping]
ELAV-like protein 3
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0007399 [nervous system development]
GO:0017091 [AU-rich element binding]
GO:0030154 [cell differentiation]
Show all
 360 aa
38.9 kDa 		No 0
ELAVL3-005
ENSP00000467314
ENST00000588853
K7EPB5 [Direct mapping]
ELAV-like protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 92 aa
9.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.