Expression of ELAVL3 in cancer - Summary - The Human Protein Atlas

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ELAVL3

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ELAVL3
Gene description	ELAV like neuron-specific RNA binding protein 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (glioma)
HPA (cell line):	Group enriched (SCLC-21H, SH-SY5Y)
HPA (normal tissue):	Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in neurons in CNS

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. CAB013066
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB013066

GENE INFORMATION
Gene name	ELAVL3 (HGNC Symbol)
Synonyms	DKFZp547J036, HUC, HUCL, MGC20653, PLE21
Description	ELAV like neuron-specific RNA binding protein 3 (HGNC Symbol)
Entrez gene summary	A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.2
Chromosome location (bp)	11451326 - 11481046
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196361 (version 83.38)
Entrez gene	1995
UniProt	Q14576 (UniProt - Evidence at transcript level)
neXtProt	NX_Q14576
Antibodypedia	ELAVL3 antibodies

PROTEIN BROWSER

ELAVL3-001	ELAVL3-002	ELAVL3-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ELAVL3-001 ENSP00000352162 ENST00000359227	Q14576 [Direct mapping] ELAV-like protein 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0007399 [nervous system development] GO:0017091 [AU-rich element binding] GO:0030154 [cell differentiation] Show all	367 aa 39.5 kDa	No	0
ELAVL3-002 ENSP00000390878 ENST00000438662	Q14576 [Direct mapping] ELAV-like protein 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0007399 [nervous system development] GO:0017091 [AU-rich element binding] GO:0030154 [cell differentiation] Show all	360 aa 38.9 kDa	No	0
ELAVL3-005 ENSP00000467314 ENST00000588853	K7EPB5 [Direct mapping] ELAV-like protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	92 aa 9.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.