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PTPN1
  • TISSUE

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    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

PTPN1

Gene description

Protein tyrosine phosphatase, non-receptor type 1

Protein class

Enzymes
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression mainly in cells of the immune system.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

Approved based on 3 antibodies.
HPA012542 , CAB009329 , CAB015217
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

PTPN1 (HGNC Symbol)

Synonyms

PTP1B

Description

Protein tyrosine phosphatase, non-receptor type 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

Chromosome

20

Cytoband

q13.13

Chromosome location (bp)

50510321 - 50585241

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000196396 (version 83.38)

Entrez gene

5770

UniProt

P18031 (UniProt - Evidence at protein level)

neXtProt

NX_P18031

Antibodypedia

PTPN1 antibodies

PROTEIN BROWSER

PTPN1-001
PTPN1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTPN1-001
ENSP00000360683
ENST00000371621
P18031 [Direct mapping]
Tyrosine-protein phosphatase non-receptor type 1
A8K3M3 [Target identity:100%; Query identity:100%]
Tyrosine-protein phosphatase non-receptor type
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006470 [protein dephosphorylation]
GO:0006987 [activation of signaling protein activity involved in unfolded protein response]
GO:0007257 [activation of JUN kinase activity]
GO:0007596 [blood coagulation]
GO:0008270 [zinc ion binding]
GO:0008286 [insulin receptor signaling pathway]
GO:0009966 [regulation of signal transduction]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0030100 [regulation of endocytosis]
GO:0030168 [platelet activation]
GO:0030948 [negative regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0030971 [receptor tyrosine kinase binding]
GO:0031410 [cytoplasmic vesicle]
GO:0031532 [actin cytoskeleton reorganization]
GO:0033157 [regulation of intracellular protein transport]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0035791 [platelet-derived growth factor receptor-beta signaling pathway]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0044822 [poly(A) RNA binding]
GO:0046626 [regulation of insulin receptor signaling pathway]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0046875 [ephrin receptor binding]
GO:0051721 [protein phosphatase 2A binding]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060334 [regulation of interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:0060338 [regulation of type I interferon-mediated signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0097443 [sorting endosome]
GO:0098554 [cytoplasmic side of endoplasmic reticulum membrane]
GO:1902202 [regulation of hepatocyte growth factor receptor signaling pathway]
GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1903896 [positive regulation of IRE1-mediated unfolded protein response]
GO:1903898 [negative regulation of PERK-mediated unfolded protein response]
GO:1990264 [peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity]
GO:2000646 [positive regulation of receptor catabolic process]
Show all
435 aa
50 kDa
No 1
PTPN1-201
ENSP00000437732
ENST00000541713
B4DSN5 [Direct mapping]
Tyrosine-protein phosphatase non-receptor type
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005783 [endoplasmic reticulum]
GO:0006470 [protein dephosphorylation]
GO:0016021 [integral component of membrane]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
Show all
362 aa
41.3 kDa
No 1

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