Expression of NBPF4 in cancer - Summary - The Human Protein Atlas

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NBPF4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NBPF4
Gene description	Neuroblastoma breakpoint family, member 4
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (breast cancer)
HPA (cell line):	Cell line enhanced (BEWO, K-562, MCF7)
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Expression in cells in seminiferous ducts.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene.
Reliability score	Uncertain based on 4 antibodies. HPA045044 , HPA046411 , HPA047447 , HPA058050
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (breast cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA045044	HPA046411	HPA047447	HPA058050

GENE INFORMATION
Gene name	NBPF4 (HGNC Symbol)
Synonyms	FLJ32833
Description	Neuroblastoma breakpoint family, member 4 (HGNC Symbol)
Entrez gene summary	This gene is a member of the neuroblastoma breakpoint family (NBPF) which consists of dozens of recently duplicated genes primarily located in segmental duplications on human chromosome 1. This gene family has experienced its greatest expansion within the human lineage and has expanded, to a lesser extent, among primates in general. Members of this gene family are characterized by tandemly repeated copies of DUF1220 protein domains. Gene copy number variations in the human chromosomal region 1q21.1, where most DUF1220 domains are located, have been implicated in a number of developmental and neurogenetic diseases such as microcephaly, macrocephaly, autism, schizophrenia, mental retardation, congenital heart disease, neuroblastoma, and congenital kidney and urinary tract anomalies. Altered expression of some gene family members is associated with several types of cancer. This gene family contains numerous pseudogenes. [provided by RefSeq, Mar 2013]
Chromosome	1
Cytoband	p13.3
Chromosome location (bp)	108223341 - 108244081
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000196427 (version 83.38)
Entrez gene	148545
UniProt	Q96M43 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96M43
Antibodypedia	NBPF4 antibodies

PROTEIN BROWSER

NBPF4-001	NBPF4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NBPF4-001 ENSP00000389237 ENST00000415641	Q96M43 [Direct mapping] Neuroblastoma breakpoint family member 4 Show all	Predicted intracellular proteins Show all	GO:0005737 [cytoplasm] Show all	638 aa 72.1 kDa	No	0
NBPF4-201 ENSP00000479545 ENST00000613157	A0A087WVM6 [Direct mapping] Neuroblastoma breakpoint family member 4 Show all	Predicted intracellular proteins Show all		667 aa 75.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.