Tissue expression of ASMT - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ASMT
Gene description	Acetylserotonin O-methyltransferase
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (epididymis)
GTEx:	Mixed
FANTOM5:	Not detected

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (epididymis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Not detected

GENE INFORMATION
Gene name	ASMT (HGNC Symbol)
Synonyms	ASMTY, HIOMT, HIOMTY
Description	Acetylserotonin O-methyltransferase (HGNC Symbol)
Entrez gene summary	This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2010]
Chromosome	X
Cytoband	p22.33
Chromosome location (bp)	1615001 - 1643081
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196433 (version 83.38)
Entrez gene	438
UniProt	P46597 (UniProt - Evidence at protein level)
neXtProt	NX_P46597
Antibodypedia	ASMT antibodies

PROTEIN BROWSER

ASMT-001	ASMT-002	ASMT-003	ASMT-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ASMT-001 ENSP00000370639 ENST00000381241	P46597 [Direct mapping] Acetylserotonin O-methyltransferase A0A024RBT9 [Target identity:100%; Query identity:100%] HCG1981394, isoform CRA_b Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Show all	GO:0005829 [cytosol] GO:0006412 [translation] GO:0008168 [methyltransferase activity] GO:0008171 [O-methyltransferase activity] GO:0008757 [S-adenosylmethionine-dependent methyltransferase activity] GO:0017096 [acetylserotonin O-methyltransferase activity] GO:0030187 [melatonin biosynthetic process] GO:0032259 [methylation] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0044281 [small molecule metabolic process] GO:0046219 [indolalkylamine biosynthetic process] Show all	373 aa 41.7 kDa	No	0
ASMT-002 ENSP00000370627 ENST00000381229	P46597 [Direct mapping] Acetylserotonin O-methyltransferase X5D2A4 [Target identity:100%; Query identity:100%] Acetylserotonin O-methyltransferase isoform B Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Show all	GO:0005829 [cytosol] GO:0006412 [translation] GO:0008168 [methyltransferase activity] GO:0008171 [O-methyltransferase activity] GO:0017096 [acetylserotonin O-methyltransferase activity] GO:0030187 [melatonin biosynthetic process] GO:0032259 [methylation] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0044281 [small molecule metabolic process] GO:0046219 [indolalkylamine biosynthetic process] Show all	345 aa 38.5 kDa	No	0
ASMT-003 ENSP00000370631 ENST00000381233	P46597 [Direct mapping] Acetylserotonin O-methyltransferase X5D784 [Target identity:100%; Query identity:100%] Acetylserotonin O-methyltransferase isoform C Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Show all	GO:0005829 [cytosol] GO:0006412 [translation] GO:0008168 [methyltransferase activity] GO:0008171 [O-methyltransferase activity] GO:0017096 [acetylserotonin O-methyltransferase activity] GO:0030187 [melatonin biosynthetic process] GO:0032259 [methylation] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0044281 [small molecule metabolic process] GO:0046219 [indolalkylamine biosynthetic process] Show all	298 aa 33.2 kDa	No	0
ASMT-004 ENSP00000392053 ENST00000432523	I7HFW6 [Direct mapping] Acetylserotonin O-methyltransferase Show all	Predicted intracellular proteins Show all	GO:0008168 [methyltransferase activity] GO:0008171 [O-methyltransferase activity] GO:0032259 [methylation] Show all	124 aa 14 kDa	No	0