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TPK1

GENERAL INFORMATION

Gene name

 TPK1

Gene description

 Thiamin pyrophosphokinase 1

Protein class

 Disease related genes
Enzymes
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (AN3-CA, EFO-21)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA021545 , HPA021849
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA021545
HPA021849

GENE INFORMATION

Gene name

 TPK1 (HGNC Symbol)

Synonyms

 HTPK1, PP20

Description

 Thiamin pyrophosphokinase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein, that exists as a homodimer, which catalyzes the conversion of thiamine to thiamine pyrophosphate. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q35

Chromosome location (bp)

 144451941 - 144836395

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196511 (version 83.38)

Entrez gene

 27010

UniProt

 Q9H3S4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H3S4

Antibodypedia

 TPK1 antibodies

PROTEIN BROWSER
TPK1-001
TPK1-007
TPK1-014
TPK1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TPK1-001
ENSP00000353165
ENST00000360057
Q9H3S4 [Direct mapping]
Thiamin pyrophosphokinase 1
A0A090N8Y0 [Target identity:100%; Query identity:100%]
Thiamin pyrophosphokinase 1
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004788 [thiamine diphosphokinase activity]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006772 [thiamine metabolic process]
GO:0009229 [thiamine diphosphate biosynthetic process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0030975 [thiamine binding]
GO:0042723 [thiamine-containing compound metabolic process]
GO:0044281 [small molecule metabolic process]
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 243 aa
27.3 kDa 		No 0
TPK1-007
ENSP00000448655
ENST00000552881
F8VRJ6 [Direct mapping]
Thiamin pyrophosphokinase 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004788 [thiamine diphosphokinase activity]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006772 [thiamine metabolic process]
GO:0009229 [thiamine diphosphate biosynthetic process]
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 167 aa
19.1 kDa 		No 0
TPK1-014
ENSP00000438813
ENST00000538212
Q6ZQX6 [Direct mapping]
Thiamin pyrophosphokinase 1; cDNA FLJ46821 fis, clone TSTOM2002611, moderately similar to Mus musculus thiamin pyrophosphokinase (Tpk1)
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004788 [thiamine diphosphokinase activity]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006772 [thiamine metabolic process]
GO:0009229 [thiamine diphosphate biosynthetic process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0030975 [thiamine binding]
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 189 aa
21 kDa 		No 0
TPK1-201
ENSP00000367339
ENST00000378099
F5GZG6 [Direct mapping]
Thiamin pyrophosphokinase 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004788 [thiamine diphosphokinase activity]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006772 [thiamine metabolic process]
GO:0009229 [thiamine diphosphate biosynthetic process]
GO:0030975 [thiamine binding]
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 194 aa
21.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.