Expression of MME in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	MME
Gene description	Membrane metallo-endopeptidase
Protein class	Cancer-related genes Candidate cardiovascular disease genes CD markers Enzymes FDA approved drug targets Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (ASC TERT1, BJ hTERT+, U-138 MG)
HPA (normal tissue):	Tissue enhanced (duodenum, kidney, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct luminal membrane expression in the small intestine, kidney, epididymis and prostate. Membranous expression in hepatocytes.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA052583 , HPA056072 , CAB000013
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA052583	HPA056072	CAB000013

GENE INFORMATION
Gene name	MME (HGNC Symbol)
Synonyms	CALLA, CD10, NEP
Description	Membrane metallo-endopeptidase (HGNC Symbol)
Entrez gene summary	This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	q25.2
Chromosome location (bp)	155024124 - 155183729
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196549 (version 83.38)
Entrez gene	4311
UniProt	P08473 (UniProt - Evidence at protein level)
neXtProt	NX_P08473
Antibodypedia	MME antibodies

PROTEIN BROWSER

MME-001	MME-003	MME-004	MME-005	MME-006	MME-007	MME-008	MME-009	MME-010	MME-011	MME-012	MME-201	MME-202	MME-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MME-001 ENSP00000418525 ENST00000460393	P08473 [Direct mapping] Neprilysin Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases CD markers MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001822 [kidney development] GO:0002003 [angiotensin maturation] GO:0004175 [endopeptidase activity] GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005903 [brush border] GO:0005925 [focal adhesion] GO:0006508 [proteolysis] GO:0006518 [peptide metabolic process] GO:0008021 [synaptic vesicle] GO:0008233 [peptidase activity] GO:0008238 [exopeptidase activity] GO:0008270 [zinc ion binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019233 [sensory perception of pain] GO:0030424 [axon] GO:0030425 [dendrite] GO:0042277 [peptide binding] GO:0044267 [cellular protein metabolic process] GO:0044306 [neuron projection terminus] GO:0045202 [synapse] GO:0046449 [creatinine metabolic process] GO:0050435 [beta-amyloid metabolic process] GO:0070062 [extracellular exosome] GO:0071345 [cellular response to cytokine stimulus] GO:0071492 [cellular response to UV-A] GO:0071493 [cellular response to UV-B] GO:0090399 [replicative senescence] Show all	750 aa 85.5 kDa	No	0
MME-003 ENSP00000372450 ENST00000382989	Q3KQS6 [Direct mapping] MME protein; Membrane metallo-endopeptidase variant 2; Neprilysin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	80 aa 8.9 kDa	No	1
MME-004 ENSP00000419653 ENST00000462745	P08473 [Direct mapping] Neprilysin Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases CD markers MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001822 [kidney development] GO:0002003 [angiotensin maturation] GO:0004175 [endopeptidase activity] GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005903 [brush border] GO:0005925 [focal adhesion] GO:0006508 [proteolysis] GO:0006518 [peptide metabolic process] GO:0008021 [synaptic vesicle] GO:0008238 [exopeptidase activity] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0019233 [sensory perception of pain] GO:0030424 [axon] GO:0030425 [dendrite] GO:0042277 [peptide binding] GO:0044267 [cellular protein metabolic process] GO:0044306 [neuron projection terminus] GO:0045202 [synapse] GO:0046449 [creatinine metabolic process] GO:0050435 [beta-amyloid metabolic process] GO:0070062 [extracellular exosome] GO:0071345 [cellular response to cytokine stimulus] GO:0071492 [cellular response to UV-A] GO:0071493 [cellular response to UV-B] GO:0090399 [replicative senescence] Show all	750 aa 85.5 kDa	No	0
MME-005 ENSP00000417079 ENST00000493237	P08473 [Direct mapping] Neprilysin Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases CD markers MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0001822 [kidney development] GO:0002003 [angiotensin maturation] GO:0004175 [endopeptidase activity] GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005903 [brush border] GO:0005925 [focal adhesion] GO:0006508 [proteolysis] GO:0006518 [peptide metabolic process] GO:0008021 [synaptic vesicle] GO:0008238 [exopeptidase activity] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0019233 [sensory perception of pain] GO:0030424 [axon] GO:0030425 [dendrite] GO:0042277 [peptide binding] GO:0044267 [cellular protein metabolic process] GO:0044306 [neuron projection terminus] GO:0045202 [synapse] GO:0046449 [creatinine metabolic process] GO:0050435 [beta-amyloid metabolic process] GO:0070062 [extracellular exosome] GO:0071345 [cellular response to cytokine stimulus] GO:0071492 [cellular response to UV-A] GO:0071493 [cellular response to UV-B] GO:0090399 [replicative senescence] Show all	750 aa 85.5 kDa	No	0
MME-006 ENSP00000353679 ENST00000360490	P08473 [Direct mapping] Neprilysin Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases CD markers MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0001822 [kidney development] GO:0002003 [angiotensin maturation] GO:0004175 [endopeptidase activity] GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005903 [brush border] GO:0005925 [focal adhesion] GO:0006508 [proteolysis] GO:0006518 [peptide metabolic process] GO:0008021 [synaptic vesicle] GO:0008238 [exopeptidase activity] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0019233 [sensory perception of pain] GO:0030424 [axon] GO:0030425 [dendrite] GO:0042277 [peptide binding] GO:0044267 [cellular protein metabolic process] GO:0044306 [neuron projection terminus] GO:0045202 [synapse] GO:0046449 [creatinine metabolic process] GO:0050435 [beta-amyloid metabolic process] GO:0070062 [extracellular exosome] GO:0071345 [cellular response to cytokine stimulus] GO:0071492 [cellular response to UV-A] GO:0071493 [cellular response to UV-B] GO:0090399 [replicative senescence] Show all	750 aa 85.5 kDa	No	0
MME-007 ENSP00000420389 ENST00000492661	P08473 [Direct mapping] Neprilysin Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases CD markers MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0001822 [kidney development] GO:0002003 [angiotensin maturation] GO:0004175 [endopeptidase activity] GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005903 [brush border] GO:0005925 [focal adhesion] GO:0006508 [proteolysis] GO:0006518 [peptide metabolic process] GO:0008021 [synaptic vesicle] GO:0008238 [exopeptidase activity] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0019233 [sensory perception of pain] GO:0030424 [axon] GO:0030425 [dendrite] GO:0042277 [peptide binding] GO:0044267 [cellular protein metabolic process] GO:0044306 [neuron projection terminus] GO:0045202 [synapse] GO:0046449 [creatinine metabolic process] GO:0050435 [beta-amyloid metabolic process] GO:0070062 [extracellular exosome] GO:0071345 [cellular response to cytokine stimulus] GO:0071492 [cellular response to UV-A] GO:0071493 [cellular response to UV-B] GO:0090399 [replicative senescence] Show all	750 aa 85.5 kDa	No	0
MME-008 ENSP00000420101 ENST00000481828	C9JR96 [Direct mapping] Neprilysin Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	233 aa 26.2 kDa	No	0
MME-009 ENSP00000418791 ENST00000491026	C9IYX7 [Direct mapping] Neprilysin Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	119 aa 13.4 kDa	No	0
MME-010 ENSP00000420542 ENST00000473730	C9JDZ3 [Direct mapping] Neprilysin Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	93 aa 10.4 kDa	No	0
MME-011 ENSP00000418238 ENST00000497890	C9J7X4 [Direct mapping] Neprilysin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		15 aa 1.7 kDa	No	0
MME-012 ENSP00000417595 ENST00000462837	C9J9X7 [Direct mapping] Neprilysin Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	161 aa 18 kDa	No	0
MME-201 ENSP00000478173 ENST00000615825	P08473 [Direct mapping] Neprilysin Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001822 [kidney development] GO:0002003 [angiotensin maturation] GO:0004175 [endopeptidase activity] GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005903 [brush border] GO:0005925 [focal adhesion] GO:0006508 [proteolysis] GO:0006518 [peptide metabolic process] GO:0008021 [synaptic vesicle] GO:0008238 [exopeptidase activity] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0019233 [sensory perception of pain] GO:0030424 [axon] GO:0030425 [dendrite] GO:0042277 [peptide binding] GO:0044267 [cellular protein metabolic process] GO:0044306 [neuron projection terminus] GO:0045202 [synapse] GO:0046449 [creatinine metabolic process] GO:0050435 [beta-amyloid metabolic process] GO:0070062 [extracellular exosome] GO:0071345 [cellular response to cytokine stimulus] GO:0071492 [cellular response to UV-A] GO:0071493 [cellular response to UV-B] GO:0090399 [replicative senescence] Show all	750 aa 85.5 kDa	No	1
MME-202 ENSP00000480349 ENST00000616757	A0A087WWM7 [Direct mapping] Neprilysin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	79 aa 8.8 kDa	No	1
MME-203 ENSP00000485791 ENST00000625667	Q3KQS6 [Direct mapping] MME protein; Membrane metallo-endopeptidase variant 2; Neprilysin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	80 aa 8.9 kDa	No	1