Fields »
ABOUT
HELP
BLOG
SULF2

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 SULF2

Gene description

 Sulfatase 2

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (hTCEpi, MCF7, EFO-21)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (hTCEpi, MCF7, EFO-21)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 SULF2 (HGNC Symbol)

Synonyms

 HSULF-2, KIAA1247, SULF-2

Description

 Sulfatase 2 (HGNC Symbol)

Entrez gene summary

 Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008]

Chromosome

 20

Cytoband

 q13.12

Chromosome location (bp)

 47656348 - 47786616

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196562 (version 83.38)

Entrez gene

 55959

UniProt

 Q8IWU5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IWU5

Antibodypedia

 SULF2 antibodies

PROTEIN BROWSER
SULF2-001
SULF2-002
SULF2-005
SULF2-007
SULF2-015

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SULF2-001
ENSP00000353007
ENST00000359930
Q8IWU5 [Direct mapping]
Extracellular sulfatase Sulf-2
Show all
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001822 [kidney development]
GO:0002063 [chondrocyte development]
GO:0003094 [glomerular filtration]
GO:0003824 [catalytic activity]
GO:0004065 [arylsulfatase activity]
GO:0005509 [calcium ion binding]
GO:0005615 [extracellular space]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005795 [Golgi stack]
GO:0005886 [plasma membrane]
GO:0008152 [metabolic process]
GO:0008449 [N-acetylglucosamine-6-sulfatase activity]
GO:0008484 [sulfuric ester hydrolase activity]
GO:0009986 [cell surface]
GO:0010575 [positive regulation of vascular endothelial growth factor production]
GO:0014846 [esophagus smooth muscle contraction]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030201 [heparan sulfate proteoglycan metabolic process]
GO:0032836 [glomerular basement membrane development]
GO:0035860 [glial cell-derived neurotrophic factor receptor signaling pathway]
GO:0040037 [negative regulation of fibroblast growth factor receptor signaling pathway]
GO:0048706 [embryonic skeletal system development]
GO:0051216 [cartilage development]
GO:0060348 [bone development]
GO:0060384 [innervation]
Show all
 870 aa
100.5 kDa 		Yes 0
SULF2-002
ENSP00000410026
ENST00000437955
B1AMP9 [Direct mapping]
Extracellular sulfatase Sulf-2
Show all
   MEMSAT3 predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
GO:0008484 [sulfuric ester hydrolase activity]
Show all
 189 aa
21.5 kDa 		Yes 0
SULF2-005
ENSP00000418290
ENST00000484875
Q8IWU5 [Direct mapping]
Extracellular sulfatase Sulf-2
Show all
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001822 [kidney development]
GO:0002063 [chondrocyte development]
GO:0003094 [glomerular filtration]
GO:0003824 [catalytic activity]
GO:0004065 [arylsulfatase activity]
GO:0005509 [calcium ion binding]
GO:0005615 [extracellular space]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005795 [Golgi stack]
GO:0005886 [plasma membrane]
GO:0008152 [metabolic process]
GO:0008449 [N-acetylglucosamine-6-sulfatase activity]
GO:0008484 [sulfuric ester hydrolase activity]
GO:0009986 [cell surface]
GO:0010575 [positive regulation of vascular endothelial growth factor production]
GO:0014846 [esophagus smooth muscle contraction]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030201 [heparan sulfate proteoglycan metabolic process]
GO:0032836 [glomerular basement membrane development]
GO:0035860 [glial cell-derived neurotrophic factor receptor signaling pathway]
GO:0040037 [negative regulation of fibroblast growth factor receptor signaling pathway]
GO:0048706 [embryonic skeletal system development]
GO:0051216 [cartilage development]
GO:0060348 [bone development]
GO:0060384 [innervation]
Show all
 870 aa
100.5 kDa 		Yes 0
SULF2-007
ENSP00000417894
ENST00000495544
H0Y872 [Direct mapping]
Extracellular sulfatase Sulf-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
Show all
 207 aa
24.4 kDa 		No 0
SULF2-015
ENSP00000418442
ENST00000467815
Q8IWU5 [Direct mapping]
Extracellular sulfatase Sulf-2
Show all
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001822 [kidney development]
GO:0002063 [chondrocyte development]
GO:0003094 [glomerular filtration]
GO:0003824 [catalytic activity]
GO:0004065 [arylsulfatase activity]
GO:0005509 [calcium ion binding]
GO:0005615 [extracellular space]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005795 [Golgi stack]
GO:0005886 [plasma membrane]
GO:0008152 [metabolic process]
GO:0008449 [N-acetylglucosamine-6-sulfatase activity]
GO:0008484 [sulfuric ester hydrolase activity]
GO:0009986 [cell surface]
GO:0010575 [positive regulation of vascular endothelial growth factor production]
GO:0014846 [esophagus smooth muscle contraction]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030201 [heparan sulfate proteoglycan metabolic process]
GO:0032836 [glomerular basement membrane development]
GO:0035860 [glial cell-derived neurotrophic factor receptor signaling pathway]
GO:0040037 [negative regulation of fibroblast growth factor receptor signaling pathway]
GO:0048706 [embryonic skeletal system development]
GO:0051216 [cartilage development]
GO:0060348 [bone development]
GO:0060384 [innervation]
Show all
 867 aa
100.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.