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Most cancer tissues showed cases of weak to moderate cytoplasmic positivity. Malignant carcinoids, melanomas, gliomas, lymphomas, testis and renal cancers were mainly negative. Positive endothelium was found in most tumors.
GENE INFORMATION
Gene name
SULF2 (HGNC Symbol)
Synonyms
HSULF-2, KIAA1247, SULF-2
Description
Sulfatase 2 (HGNC Symbol)
Entrez gene summary
Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008]