Cell atlas - HRH1 - The Human Protein Atlas

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HRH1

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Plasma membrane

Human cell
	Cytosol
	Plasma Membrane

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GENERAL INFORMATION
Gene name	HRH1
Gene description	Histamine receptor H1
Protein class	FDA approved drug targets G-protein coupled receptors Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane. In addition localized to the cytosol.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (supported)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA029740
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane. In addition localized to the cytosol.

Main location

Plasma membrane (supported)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA029740	A-431	Plasma membrane
	HPA029740	A-431	Cytosol
	HPA029740	U-2 OS	Plasma membrane
	HPA029740	U-251 MG	Plasma membrane
	HPA029740	U-251 MG	Cytosol

GENE INFORMATION
Gene name	HRH1
Synonyms
Description	Histamine receptor H1 (HGNC Symbol)
Entrez gene summary	Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2015]
Chromosome	3
Cytoband	p25.3
Chromosome location (bp)	11137093 - 11263557
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196639 (version 83.38)
Entrez gene	3269
UniProt	P35367 (UniProt - Evidence at protein level)
neXtProt	NX_P35367
Antibodypedia	HRH1 antibodies

PROTEIN BROWSER

HRH1-001	HRH1-002	HRH1-003	HRH1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HRH1-001 ENSP00000380247 ENST00000397056	P35367 [Direct mapping] Histamine H1 receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004969 [histamine receptor activity] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006954 [inflammatory response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007606 [sensory perception of chemical stimulus] GO:0007613 [memory] GO:0008542 [visual learning] GO:0016021 [integral component of membrane] GO:0019229 [regulation of vasoconstriction] GO:0032962 [positive regulation of inositol trisphosphate biosynthetic process] GO:0043114 [regulation of vascular permeability] GO:0045907 [positive regulation of vasoconstriction] GO:0048016 [inositol phosphate-mediated signaling] GO:0048167 [regulation of synaptic plasticity] GO:0048245 [eosinophil chemotaxis] GO:0050804 [modulation of synaptic transmission] GO:0051381 [histamine binding] GO:0071420 [cellular response to histamine] Show all	487 aa 55.8 kDa	No	7
HRH1-002 ENSP00000406705 ENST00000438284	P35367 [Direct mapping] Histamine H1 receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004969 [histamine receptor activity] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006954 [inflammatory response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007606 [sensory perception of chemical stimulus] GO:0016021 [integral component of membrane] GO:0019229 [regulation of vasoconstriction] GO:0032962 [positive regulation of inositol trisphosphate biosynthetic process] GO:0043114 [regulation of vascular permeability] GO:0045907 [positive regulation of vasoconstriction] GO:0048016 [inositol phosphate-mediated signaling] GO:0048245 [eosinophil chemotaxis] GO:0050804 [modulation of synaptic transmission] GO:0051381 [histamine binding] GO:0071420 [cellular response to histamine] Show all	487 aa 55.8 kDa	No	7
HRH1-003 ENSP00000397028 ENST00000431010	P35367 [Direct mapping] Histamine H1 receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004969 [histamine receptor activity] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006954 [inflammatory response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007606 [sensory perception of chemical stimulus] GO:0016021 [integral component of membrane] GO:0019229 [regulation of vasoconstriction] GO:0032962 [positive regulation of inositol trisphosphate biosynthetic process] GO:0043114 [regulation of vascular permeability] GO:0045907 [positive regulation of vasoconstriction] GO:0048016 [inositol phosphate-mediated signaling] GO:0048245 [eosinophil chemotaxis] GO:0050804 [modulation of synaptic transmission] GO:0051381 [histamine binding] GO:0071420 [cellular response to histamine] Show all	487 aa 55.8 kDa	No	7
HRH1-004 ENSP00000392383 ENST00000413416	C9J2E6 [Direct mapping] Histamine H1 receptor Show all	Predicted intracellular proteins Show all	GO:0007606 [sensory perception of chemical stimulus] GO:0019229 [regulation of vasoconstriction] GO:0050804 [modulation of synaptic transmission] GO:0051381 [histamine binding] Show all	12 aa 1.3 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.