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HRH1

GENERAL INFORMATION

Gene name

 HRH1

Gene description

 Histamine receptor H1

Protein class

 FDA approved drug targets
G-protein coupled receptors
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues, including smooth muscle.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 1 antibody.
HPA029740
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA029740

GENE INFORMATION

Gene name

 HRH1

Synonyms

Description

 Histamine receptor H1 (HGNC Symbol)

Entrez gene summary

 Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2015]

Chromosome

 3

Cytoband

 p25.3

Chromosome location (bp)

 11137093 - 11263557

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196639 (version 83.38)

Entrez gene

 3269

UniProt

 P35367 (UniProt - Evidence at protein level)

neXtProt

 NX_P35367

Antibodypedia

 HRH1 antibodies

PROTEIN BROWSER
HRH1-001
HRH1-002
HRH1-003
HRH1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HRH1-001
ENSP00000380247
ENST00000397056
P35367 [Direct mapping]
Histamine H1 receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004969 [histamine receptor activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006954 [inflammatory response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007606 [sensory perception of chemical stimulus]
GO:0007613 [memory]
GO:0008542 [visual learning]
GO:0016021 [integral component of membrane]
GO:0019229 [regulation of vasoconstriction]
GO:0032962 [positive regulation of inositol trisphosphate biosynthetic process]
GO:0043114 [regulation of vascular permeability]
GO:0045907 [positive regulation of vasoconstriction]
GO:0048016 [inositol phosphate-mediated signaling]
GO:0048167 [regulation of synaptic plasticity]
GO:0048245 [eosinophil chemotaxis]
GO:0050804 [modulation of synaptic transmission]
GO:0051381 [histamine binding]
GO:0071420 [cellular response to histamine]
Show all
 487 aa
55.8 kDa 		No 7
HRH1-002
ENSP00000406705
ENST00000438284
P35367 [Direct mapping]
Histamine H1 receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004969 [histamine receptor activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006954 [inflammatory response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007606 [sensory perception of chemical stimulus]
GO:0016021 [integral component of membrane]
GO:0019229 [regulation of vasoconstriction]
GO:0032962 [positive regulation of inositol trisphosphate biosynthetic process]
GO:0043114 [regulation of vascular permeability]
GO:0045907 [positive regulation of vasoconstriction]
GO:0048016 [inositol phosphate-mediated signaling]
GO:0048245 [eosinophil chemotaxis]
GO:0050804 [modulation of synaptic transmission]
GO:0051381 [histamine binding]
GO:0071420 [cellular response to histamine]
Show all
 487 aa
55.8 kDa 		No 7
HRH1-003
ENSP00000397028
ENST00000431010
P35367 [Direct mapping]
Histamine H1 receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004969 [histamine receptor activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006954 [inflammatory response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007606 [sensory perception of chemical stimulus]
GO:0016021 [integral component of membrane]
GO:0019229 [regulation of vasoconstriction]
GO:0032962 [positive regulation of inositol trisphosphate biosynthetic process]
GO:0043114 [regulation of vascular permeability]
GO:0045907 [positive regulation of vasoconstriction]
GO:0048016 [inositol phosphate-mediated signaling]
GO:0048245 [eosinophil chemotaxis]
GO:0050804 [modulation of synaptic transmission]
GO:0051381 [histamine binding]
GO:0071420 [cellular response to histamine]
Show all
 487 aa
55.8 kDa 		No 7
HRH1-004
ENSP00000392383
ENST00000413416
C9J2E6 [Direct mapping]
Histamine H1 receptor
Show all
Predicted intracellular proteins
Show all
GO:0007606 [sensory perception of chemical stimulus]
GO:0019229 [regulation of vasoconstriction]
GO:0050804 [modulation of synaptic transmission]
GO:0051381 [histamine binding]
Show all
 12 aa
1.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.