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HSH2D

GENERAL INFORMATION

Gene name

 HSH2D

Gene description

 Hematopoietic SH2 domain containing

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (HMC-1, NB-4, U-937)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), colorectal cancer (unfavourable) and urothelial cancer (favourable).
Renal cancer p<0.001
Colorectal cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 HSH2D (HGNC Symbol)

Synonyms

 ALX, FLJ14886, HSH2

Description

 Hematopoietic SH2 domain containing (HGNC Symbol)

Entrez gene summary

 T-cell activation requires 2 signals: recognition of antigen by the T-cell receptor (see TCR; MIM 186880) and a costimulatory signal provided primarily by CD28 (MIM 186760) in naive T cells. HSH2 is a target of both of these signaling pathways (Greene et al., 2003 [PubMed 12960172]).[supplied by OMIM, Mar 2008]

Chromosome

 19

Cytoband

 p13.11

Chromosome location (bp)

 16134028 - 16158575

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196684 (version 83.38)

Entrez gene

 84941

UniProt

 Q96JZ2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96JZ2

Antibodypedia

 HSH2D antibodies

PROTEIN BROWSER
HSH2D-001
HSH2D-007
HSH2D-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HSH2D-001
ENSP00000483354
ENST00000613986
Q96JZ2 [Direct mapping]
Hematopoietic SH2 domain-containing protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005634 [nucleus]
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 352 aa
39 kDa 		No 0
HSH2D-007
ENSP00000467189
ENST00000593031
K7EP18 [Direct mapping]
Hematopoietic SH2 domain-containing protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 173 aa
19.2 kDa 		No 0
HSH2D-009
ENSP00000482604
ENST00000616645
Q96JZ2 [Direct mapping]
Hematopoietic SH2 domain-containing protein
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002903 [negative regulation of B cell apoptotic process]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0009967 [positive regulation of signal transduction]
GO:0042110 [T cell activation]
GO:0051902 [negative regulation of mitochondrial depolarization]
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 352 aa
39 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.