Tissue expression of HSH2D - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	HSH2D
Gene description	Hematopoietic SH2 domain containing
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Tissue enhanced (small intestine, spleen)
FANTOM5:	Tissue enhanced (appendix, tonsil)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (small intestine, spleen)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (appendix, tonsil)

GENE INFORMATION
Gene name	HSH2D (HGNC Symbol)
Synonyms	ALX, FLJ14886, HSH2
Description	Hematopoietic SH2 domain containing (HGNC Symbol)
Entrez gene summary	T-cell activation requires 2 signals: recognition of antigen by the T-cell receptor (see TCR; MIM 186880) and a costimulatory signal provided primarily by CD28 (MIM 186760) in naive T cells. HSH2 is a target of both of these signaling pathways (Greene et al., 2003 [PubMed 12960172]).[supplied by OMIM, Mar 2008]
Chromosome	19
Cytoband	p13.11
Chromosome location (bp)	16134028 - 16158575
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196684 (version 83.38)
Entrez gene	84941
UniProt	Q96JZ2 (UniProt - Evidence at protein level)
neXtProt	NX_Q96JZ2
Antibodypedia	HSH2D antibodies

PROTEIN BROWSER

HSH2D-001	HSH2D-007	HSH2D-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HSH2D-001 ENSP00000483354 ENST00000613986	Q96JZ2 [Direct mapping] Hematopoietic SH2 domain-containing protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] Show all	352 aa 39 kDa	No	0
HSH2D-007 ENSP00000467189 ENST00000593031	K7EP18 [Direct mapping] Hematopoietic SH2 domain-containing protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		173 aa 19.2 kDa	No	0
HSH2D-009 ENSP00000482604 ENST00000616645	Q96JZ2 [Direct mapping] Hematopoietic SH2 domain-containing protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002903 [negative regulation of B cell apoptotic process] GO:0005070 [SH3/SH2 adaptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0009967 [positive regulation of signal transduction] GO:0042110 [T cell activation] GO:0051902 [negative regulation of mitochondrial depolarization] Show all	352 aa 39 kDa	No	0