Expression of DAPK1 in cancer - Summary - The Human Protein Atlas

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DAPK1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DAPK1
Gene description	Death-associated protein kinase 1
Protein class	Cancer-related genes Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HMC-1)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 3 antibodies. HPA040472 , HPA048436 , CAB037302
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (unfavourable).
Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA040472	HPA048436	CAB037302

GENE INFORMATION
Gene name	DAPK1 (HGNC Symbol)
Synonyms	DAPK
Description	Death-associated protein kinase 1 (HGNC Symbol)
Entrez gene summary	Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Chromosome	9
Cytoband	q21.33
Chromosome location (bp)	87497228 - 87708633
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196730 (version 83.38)
Entrez gene	1612
UniProt	P53355 (UniProt - Evidence at protein level)
neXtProt	NX_P53355
Antibodypedia	DAPK1 antibodies

PROTEIN BROWSER

DAPK1-001	DAPK1-008	DAPK1-010	DAPK1-011	DAPK1-201	DAPK1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DAPK1-001 ENSP00000350785 ENST00000358077	P53355 [Direct mapping] Death-associated protein kinase 1 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0010506 [regulation of autophagy] GO:0012501 [programmed cell death] GO:0015629 [actin cytoskeleton] GO:0017075 [syntaxin-1 binding] GO:0017148 [negative regulation of translation] GO:0035556 [intracellular signal transduction] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0046777 [protein autophosphorylation] GO:0071346 [cellular response to interferon-gamma] GO:0097190 [apoptotic signaling pathway] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity] Show all	1430 aa 160 kDa	No	1
DAPK1-008 ENSP00000417076 ENST00000472284	P53355 [Direct mapping] Death-associated protein kinase 1 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0010506 [regulation of autophagy] GO:0012501 [programmed cell death] GO:0015629 [actin cytoskeleton] GO:0017075 [syntaxin-1 binding] GO:0017148 [negative regulation of translation] GO:0035556 [intracellular signal transduction] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0046777 [protein autophosphorylation] GO:0071346 [cellular response to interferon-gamma] GO:0097190 [apoptotic signaling pathway] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity] Show all	1430 aa 160 kDa	No	1
DAPK1-010 ENSP00000386135 ENST00000408954	P53355 [Direct mapping] Death-associated protein kinase 1 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] GO:0010506 [regulation of autophagy] GO:0012501 [programmed cell death] GO:0015629 [actin cytoskeleton] GO:0017075 [syntaxin-1 binding] GO:0017148 [negative regulation of translation] GO:0035556 [intracellular signal transduction] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0046777 [protein autophosphorylation] GO:0071346 [cellular response to interferon-gamma] GO:0097190 [apoptotic signaling pathway] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity] Show all	1430 aa 160 kDa	No	1
DAPK1-011 ENSP00000419026 ENST00000491893	P53355 [Direct mapping] Death-associated protein kinase 1 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0010506 [regulation of autophagy] GO:0012501 [programmed cell death] GO:0015629 [actin cytoskeleton] GO:0017075 [syntaxin-1 binding] GO:0017148 [negative regulation of translation] GO:0035556 [intracellular signal transduction] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0046777 [protein autophosphorylation] GO:0071346 [cellular response to interferon-gamma] GO:0097190 [apoptotic signaling pathway] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity] Show all	1364 aa 152.5 kDa	No	1
DAPK1-201 ENSP00000418885 ENST00000469640	P53355 [Direct mapping] Death-associated protein kinase 1 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0010506 [regulation of autophagy] GO:0012501 [programmed cell death] GO:0015629 [actin cytoskeleton] GO:0017075 [syntaxin-1 binding] GO:0017148 [negative regulation of translation] GO:0035556 [intracellular signal transduction] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0046777 [protein autophosphorylation] GO:0071346 [cellular response to interferon-gamma] GO:0097190 [apoptotic signaling pathway] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity] Show all	1364 aa 152.5 kDa	No	1
DAPK1-202 ENSP00000484267 ENST00000622514	P53355 [Direct mapping] Death-associated protein kinase 1 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0010506 [regulation of autophagy] GO:0012501 [programmed cell death] GO:0015629 [actin cytoskeleton] GO:0017075 [syntaxin-1 binding] GO:0017148 [negative regulation of translation] GO:0035556 [intracellular signal transduction] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0046777 [protein autophosphorylation] GO:0071346 [cellular response to interferon-gamma] GO:0097190 [apoptotic signaling pathway] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity] Show all	1430 aa 160 kDa	No	1

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