Tissue expression of DAPK1 - Summary - The Human Protein Atlas

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DAPK1

TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	DAPK1
Gene description	Death-associated protein kinase 1
Protein class	Cancer-related genes Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 3 antibodies. HPA040472 , HPA048436 , CAB037302
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	DAPK1 (HGNC Symbol)
Synonyms	DAPK
Description	Death-associated protein kinase 1 (HGNC Symbol)
Entrez gene summary	Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Chromosome	9
Cytoband	q21.33
Chromosome location (bp)	87497228 - 87708633
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196730 (version 83.38)
Entrez gene	1612
UniProt	P53355 (UniProt - Evidence at protein level)
neXtProt	NX_P53355
Antibodypedia	DAPK1 antibodies

PROTEIN BROWSER

DAPK1-001	DAPK1-008	DAPK1-010	DAPK1-011	DAPK1-201	DAPK1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DAPK1-001 ENSP00000350785 ENST00000358077	P53355 [Direct mapping] Death-associated protein kinase 1 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0010506 [regulation of autophagy] GO:0012501 [programmed cell death] GO:0015629 [actin cytoskeleton] GO:0017075 [syntaxin-1 binding] GO:0017148 [negative regulation of translation] GO:0035556 [intracellular signal transduction] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0046777 [protein autophosphorylation] GO:0071346 [cellular response to interferon-gamma] GO:0097190 [apoptotic signaling pathway] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity] Show all	1430 aa 160 kDa	No	1
DAPK1-008 ENSP00000417076 ENST00000472284	P53355 [Direct mapping] Death-associated protein kinase 1 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0010506 [regulation of autophagy] GO:0012501 [programmed cell death] GO:0015629 [actin cytoskeleton] GO:0017075 [syntaxin-1 binding] GO:0017148 [negative regulation of translation] GO:0035556 [intracellular signal transduction] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0046777 [protein autophosphorylation] GO:0071346 [cellular response to interferon-gamma] GO:0097190 [apoptotic signaling pathway] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity] Show all	1430 aa 160 kDa	No	1
DAPK1-010 ENSP00000386135 ENST00000408954	P53355 [Direct mapping] Death-associated protein kinase 1 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] GO:0010506 [regulation of autophagy] GO:0012501 [programmed cell death] GO:0015629 [actin cytoskeleton] GO:0017075 [syntaxin-1 binding] GO:0017148 [negative regulation of translation] GO:0035556 [intracellular signal transduction] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0046777 [protein autophosphorylation] GO:0071346 [cellular response to interferon-gamma] GO:0097190 [apoptotic signaling pathway] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity] Show all	1430 aa 160 kDa	No	1
DAPK1-011 ENSP00000419026 ENST00000491893	P53355 [Direct mapping] Death-associated protein kinase 1 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0010506 [regulation of autophagy] GO:0012501 [programmed cell death] GO:0015629 [actin cytoskeleton] GO:0017075 [syntaxin-1 binding] GO:0017148 [negative regulation of translation] GO:0035556 [intracellular signal transduction] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0046777 [protein autophosphorylation] GO:0071346 [cellular response to interferon-gamma] GO:0097190 [apoptotic signaling pathway] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity] Show all	1364 aa 152.5 kDa	No	1
DAPK1-201 ENSP00000418885 ENST00000469640	P53355 [Direct mapping] Death-associated protein kinase 1 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0010506 [regulation of autophagy] GO:0012501 [programmed cell death] GO:0015629 [actin cytoskeleton] GO:0017075 [syntaxin-1 binding] GO:0017148 [negative regulation of translation] GO:0035556 [intracellular signal transduction] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0046777 [protein autophosphorylation] GO:0071346 [cellular response to interferon-gamma] GO:0097190 [apoptotic signaling pathway] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity] Show all	1364 aa 152.5 kDa	No	1
DAPK1-202 ENSP00000484267 ENST00000622514	P53355 [Direct mapping] Death-associated protein kinase 1 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0010506 [regulation of autophagy] GO:0012501 [programmed cell death] GO:0015629 [actin cytoskeleton] GO:0017075 [syntaxin-1 binding] GO:0017148 [negative regulation of translation] GO:0035556 [intracellular signal transduction] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0046777 [protein autophosphorylation] GO:0071346 [cellular response to interferon-gamma] GO:0097190 [apoptotic signaling pathway] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity] Show all	1430 aa 160 kDa	No	1

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