Cell atlas - S100A2 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	S100A2
Gene description	S100 calcium binding protein A2
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus & cytosol. In addition localized to the nucleoli & plasma membrane.
RNA cell category	Cell line enhanced (RT4, hTCEpi, HaCaT)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported), Cytosol (supported)
Additional location	In addition localized to the Nucleoli (approved), Plasma membrane (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. CAB002600
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RT4, hTCEpi, HaCaT) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus & cytosol. In addition localized to the nucleoli & plasma membrane.

Main location

Nucleus (supported), Cytosol (supported)

Additional location

Nucleoli (approved), Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
CAB002600	A-431	Nucleoplasm	Spatial
		Plasma membrane
		Cytosol	Spatial
CAB002600	U-2 OS	Nucleus	Spatial
		Nucleoli
		Plasma membrane
		Cytosol	Spatial
CAB002600	U-251 MG	Nucleus	Spatial
		Plasma membrane
		Cytosol	Spatial

GENE INFORMATION
Gene name	S100A2 (HGNC Symbol)
Synonyms	CAN19, S100L
Description	S100 calcium binding protein A2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may have a tumor suppressor function. Chromosomal rearrangements and altered expression of this gene have been implicated in breast cancer. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q21.3
Chromosome location (bp)	153561108 - 153567890
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196754 (version 83.38)
Entrez gene	6273
UniProt	P29034 (UniProt - Evidence at protein level)
neXtProt	NX_P29034
Antibodypedia	S100A2 antibodies

PROTEIN BROWSER

S100A2-001	S100A2-002	S100A2-003	S100A2-004	S100A2-005	S100A2-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
S100A2-001 ENSP00000357697 ENST00000368708	P29034 [Direct mapping] Protein S100-A2 Show all	Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0042802 [identical protein binding] GO:0043542 [endothelial cell migration] Show all	97 aa 11 kDa	No	0
S100A2-002 ENSP00000357698 ENST00000368709	P29034 [Direct mapping] Protein S100-A2 Show all	Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0042802 [identical protein binding] GO:0043542 [endothelial cell migration] Show all	97 aa 11 kDa	No	0
S100A2-003 ENSP00000357699 ENST00000368710	P29034 [Direct mapping] Protein S100-A2 Show all	Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0042802 [identical protein binding] GO:0043542 [endothelial cell migration] Show all	97 aa 11 kDa	No	0
S100A2-004 ENSP00000357696 ENST00000368707	Q5RHS7 [Direct mapping] Protein S100-A2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		95 aa 11 kDa	No	0
S100A2-005 ENSP00000473260 ENST00000487430	P29034 [Direct mapping] Protein S100-A2 Show all	Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0042802 [identical protein binding] GO:0043542 [endothelial cell migration] Show all	97 aa 11 kDa	No	0
S100A2-006 ENSP00000473489 ENST00000497140	R4GN49 [Direct mapping] Protein S100-A2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	64 aa 7.3 kDa	No	0