Expression of S100A2 in cancer - Summary

GENERAL INFORMATION
Gene name	S100A2
Gene description	S100 calcium binding protein A2
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HaCaT, hTCEpi, RT4)
HPA (normal tissue):	Tissue enhanced (esophagus, tonsil)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in urothelium, respiratory and squamous epithelium.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA062451 , CAB002600 , CAB047340
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA062451	CAB002600	CAB047340

GENE INFORMATION
Gene name	S100A2 (HGNC Symbol)
Synonyms	CAN19, S100L
Description	S100 calcium binding protein A2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may have a tumor suppressor function. Chromosomal rearrangements and altered expression of this gene have been implicated in breast cancer. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q21.3
Chromosome location (bp)	153561108 - 153567890
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196754 (version 83.38)
Entrez gene	6273
UniProt	P29034 (UniProt - Evidence at protein level)
neXtProt	NX_P29034
Antibodypedia	S100A2 antibodies

PROTEIN BROWSER

S100A2-001	S100A2-002	S100A2-003	S100A2-004	S100A2-005	S100A2-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
S100A2-001 ENSP00000357697 ENST00000368708	P29034 [Direct mapping] Protein S100-A2 Show all	Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0042802 [identical protein binding] GO:0043542 [endothelial cell migration] Show all	97 aa 11 kDa	No	0
S100A2-002 ENSP00000357698 ENST00000368709	P29034 [Direct mapping] Protein S100-A2 Show all	Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0042802 [identical protein binding] GO:0043542 [endothelial cell migration] Show all	97 aa 11 kDa	No	0
S100A2-003 ENSP00000357699 ENST00000368710	P29034 [Direct mapping] Protein S100-A2 Show all	Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0042802 [identical protein binding] GO:0043542 [endothelial cell migration] Show all	97 aa 11 kDa	No	0
S100A2-004 ENSP00000357696 ENST00000368707	Q5RHS7 [Direct mapping] Protein S100-A2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		95 aa 11 kDa	No	0
S100A2-005 ENSP00000473260 ENST00000487430	P29034 [Direct mapping] Protein S100-A2 Show all	Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0042802 [identical protein binding] GO:0043542 [endothelial cell migration] Show all	97 aa 11 kDa	No	0
S100A2-006 ENSP00000473489 ENST00000497140	R4GN49 [Direct mapping] Protein S100-A2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	64 aa 7.3 kDa	No	0