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MAML3

GENERAL INFORMATION

Gene name

 MAML3

Gene description

 Mastermind-like transcriptional coactivator 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (SCLC-21H, SH-SY5Y, WM-115)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA037717
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA037717

GENE INFORMATION

Gene name

 MAML3 (HGNC Symbol)

Synonyms

 CAGH3, GDN, KIAA1816, MAM2, TNRC3

Description

 Mastermind-like transcriptional coactivator 3 (HGNC Symbol)

Entrez gene summary

Chromosome

 4

Cytoband

 q31.1

Chromosome location (bp)

 139716753 - 140154184

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196782 (version 83.38)

Entrez gene

 55534

UniProt

 Q96JK9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96JK9

Antibodypedia

 MAML3 antibodies

PROTEIN BROWSER
MAML3-001
MAML3-002
MAML3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAML3-001
ENSP00000421180
ENST00000509479
Q96JK9 [Direct mapping]
Mastermind-like protein 3
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Predicted intracellular proteins
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GO:0003713 [transcription coactivator activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007219 [Notch signaling pathway]
GO:0010467 [gene expression]
GO:0016607 [nuclear speck]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
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 1138 aa
122.3 kDa 		No 0
MAML3-002
ENSP00000422783
ENST00000502696
H0Y920 [Direct mapping]
Mastermind-like protein 3
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Predicted intracellular proteins
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 186 aa
20.2 kDa 		No 0
MAML3-201
ENSP00000381913
ENST00000398940
E7ESR8 [Direct mapping]
Mastermind-like protein 3
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Predicted intracellular proteins
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 276 aa
31.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.