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MVB12B

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GENERAL INFORMATION

Gene name

 MVB12B

Gene description

 Multivesicular body subunit 12B

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the Golgi apparatus & vesicles.

RNA cell category

 Cell line enhanced (AF22)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Golgi apparatus (approved), Vesicles (approved)

DATA RELIABILITY

Reliability score

 Approved based on 2 antibodies.
HPA043683 , HPA049383
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (AF22)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the Golgi apparatus & vesicles.

Main location

 Golgi apparatus (approved), Vesicles (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA043683 Hep G2 Vesicles
HPA043683 RH-30 No staining    
HPA049383 Hep G2 Golgi apparatus
HPA049383 RH-30 Golgi apparatus
HPA049383 U-2 OS Golgi apparatus

GENE INFORMATION

Gene name

 MVB12B (HGNC Symbol)

Synonyms

 C9orf28, FAM125B, FLJ00001

Description

 Multivesicular body subunit 12B (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. ESCRT-I complex plays an essential role in HIV budding and endosomal protein sorting. Depletion and overexpression of this and related protein (MVB12A) inhibit HIV-1 infectivity and induce unusual viral assembly defects, indicating a role for MVB12 subunits in regulating ESCRT-mediated virus budding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Chromosome

 9

Cytoband

 q33.3

Chromosome location (bp)

 126326849 - 126507041

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196814 (version 83.38)

Entrez gene

 89853

UniProt

 Q9H7P6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H7P6

Antibodypedia

 MVB12B antibodies

PROTEIN BROWSER
MVB12B-001
MVB12B-002
MVB12B-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MVB12B-001
ENSP00000354772
ENST00000361171
Q9H7P6 [Direct mapping]
Multivesicular body subunit 12B
A0A024R8B8 [Target identity:100%; Query identity:100%]
Chromosome 9 open reading frame 28, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000813 [ESCRT I complex]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0008289 [lipid binding]
GO:0015031 [protein transport]
GO:0019075 [virus maturation]
GO:0031902 [late endosome membrane]
GO:0031982 [vesicle]
GO:0042058 [regulation of epidermal growth factor receptor signaling pathway]
GO:0043162 [ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway]
GO:0048524 [positive regulation of viral process]
GO:0070062 [extracellular exosome]
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 319 aa
35.6 kDa 		No 0
MVB12B-002
ENSP00000485994
ENST00000489637
Q9H7P6 [Direct mapping]
Multivesicular body subunit 12B
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000813 [ESCRT I complex]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0008289 [lipid binding]
GO:0015031 [protein transport]
GO:0019075 [virus maturation]
GO:0031902 [late endosome membrane]
GO:0031982 [vesicle]
GO:0042058 [regulation of epidermal growth factor receptor signaling pathway]
GO:0043162 [ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway]
GO:0048524 [positive regulation of viral process]
GO:0070062 [extracellular exosome]
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 221 aa
24.5 kDa 		No 0
MVB12B-004
ENSP00000384751
ENST00000402437
F8W922 [Direct mapping]
Multivesicular body subunit 12B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 205 aa
22.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.